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Prostacyclin in diarrhoea-associated haemolytic uraemic syndrome

, : Prostacyclin in diarrhoea-associated haemolytic uraemic syndrome. Pediatric Nephrology 7(5): 515-519

The role of prostacyclin (PGI-2) in the pathogenesis of haemolytic uraemic syndrome (HUS) is controversial. In part, confusion has been caused by failure to distinguish between two main sub-types of the syndrome: extrinsic, diarrhoea-associated HUS (D+ HUS), usually caused by infection with verocytotoxin-producing Escherichia coli or Shigella dysenteriae, and the heterogeneous group of non-prodromal forms where intrinsic factors predominate (D-HUS). This paper critically reviews data confined to D+ HUS. Two methods have been used to assess PGI-2 synthesis; the generation of PGI-2 from endothelium in the presence of HUS plasma in vitro and the measurement of stable metabolites in body fluids. No consensus could be reached with regard to the former. The reported increase of PGI-2 stable metabolites in plasma may represent reduced clearance or increased carriage by plasma lipids. Apparent differences between studies of urinary excretion of PGI-2 metabolites may reflect the way excretion was expressed. If the metabolite concentration is factored for urinary creatinine, it appears that renal excretion and thus renal synthesis of PGI-2 is reduced. However, these are insufficient data on which to attribute the pathogenesis of D+ HUS to disordered PGI-2 metabolism.


PMID: 8251312

DOI: 10.1007/bf00852530

Other references

Huynh, Kl, 1984: Pandanus (Pandanaceae) from West Africa. 1. Bulletin du Museum national d'histoire naturelle Section B: Adansonia botanique phytochimie(3): 335-358

Sztrilich, P., 1973: The incidence of traumatic retrusion of the mandibular condyle in clinical practice. Fogorvosi Szemle 66(7): 204-209

Via Boada, L., 1967: Leucosidos y caiapidos Eocenicos de Espana. Contribucion al estudio paleontologico de !a subtribu Oxystomata (Crustaceous Decapodos). Notas y Comunicaciones del Instituto Geologico y Minero de Espana, 99-100: 5-42

Sibirkin, N.V.; Kozlovich, I.V.; Iazovitskaia, L.M., 1974: Experience with the treatment of hypertensive disease with octadin. Klinicheskaia Meditsina 52(8): 62-67

Delucia, M.C.; Carpenter, T.O., 2001: Serum 25-hydroxyvitamin D levels are usually normal in nutritional rickets. Pediatric Research 49(4 Part 2): 108A, April

Honda, T.; Eliot, M.N.; Eaton, C.B.; Whitsel, E.; Stewart, J.D.; Mu, L.; Suh, H.; Szpiro, A.; Kaufman, J.D.; Vedal, S.; Wellenius, G.A., 2017: Long-term exposure to residential ambient fine and coarse particulate matter and incident hypertension in post-menopausal women. Long-term exposure to ambient particulate matter (PM) has been previously linked with higher risk of cardiovascular events. This association may be mediated, at least partly, by increasing the risk of incident hypertension, a key determinant of ca...

Hantschke, D., 1971: Infestation of the head by the pathogenic agent of pityriasis versicolor. Zeitschrift für Haut- und Geschlechtskrankheiten 46(3): 79-80

Kan, K.W.; Cruess, R.L., 1986: Gestational changes in the level of glucocorticoid-binding sites in fetal bovine cartilaginous tissues. In order to assess glucocorticoid actions on fetal cartilage development, [3H]dexamethasone binding site levels in fetal bovine cartilaginous tissues from long bones were measured, using a whole cell assay at 37 degrees C. Displaceable [3H]dexamet...

Clague John J.; Evans Stephen G., 1998: Natural hazards in the Canadian Cordillera. Proceedings - International Congress of the International Association for Engineering Geology and the Environment 8, Vol

Manley, B.; Goulding-Cj; Lawrence, M., 1987: Stand assessment by log grades using MARVL. FRI bulletin Forest Research Institute New Zealand Forest Service: (132)