geoscience.net logo
+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Protective effect of chronic NSAID use on cognitive decline in older persons


, : Protective effect of chronic NSAID use on cognitive decline in older persons. Journal of the American Geriatrics Society 44(9): 1025-1029

OBJECTIVE: To verify whether chronic use of nonsteroidal anti-inflammatory drugs (NSAIDs) has a protective effect against cognitive decline in older persons. DESIGN: Prospective study with a 3-year observation period. SETTING: Three communities of the Established Populations for Epidemiologic Studies of the Elderly (EPESE). SUBJECTS: A population-based sample of 7671 subjects who received an in-person interview at the sixth annual follow-up. Persons with documented NSAID use at the time of the interview and 3 years before were considered chronic users (21%), while all other persons were considered as nonusers. MAIN OUTCOME MEASURE: Change over time in cognitive function assessed as the number of correct answers to a 9-item version of the Short Portable Mental Status Questionnaire (SPMSQ). RESULTS: For every level of SPMSQ score measured at the beginning of the observation period, the mean SPMSQ score after 3 years was higher in chronic NSAID users than in nonusers. Cognitive function at the end of the observation period was significantly higher in chronic NSAID users than in controls, adjusting for initial SPMSQ score and potential confounders. Older age, female gender, education, and history of cerebrovascular disease were also independent predictors of lower SPMSQ score. In the multivariate analysis, the magnitude of the protective effect estimated for NSAID use was comparable to a difference in age of 3.5 years. The percentage of persons who started above a specific SPMSQ score cut-point and deteriorated below that cut-point over a 3-year period was significantly lower in chronic NSAID users than in nonusers (30.2% vs 34.3%, P = .03, for decline below SPMSQ score of 8 and 12.3% vs 14.4% for decline below SPMSQ score of 6, P = .04). After controlling for potential confounders, the relative risk of cognitive declining in chronic NSAID users compared with nonusers was 0.82 (95% Confidence Interval: 0.69-0.98) for a decline below a score of 8, and 0.80 (95% CI: 0.66-0.98) for a decline below a score of 6. CONCLUSIONS: These results support the association between NSAID use and reduction in cognitive decline in older persons. Ultimately, randomized controlled trials must be done to prove a beneficial effect definitively.

US$19.90

PMID: 8790225

DOI: 10.1111/j.1532-5415.1996.tb02932.x


Other references

Brennan, A.; Manalac, M.; O'neill, A.M.; Russell, K.; Dembicki, R.; Yurt, R.W., 1999: Kitchen injuries Prevalence in elderly females. Journal of Burn Care & Rehabilitation 20(1 PART 2): S271, Jan -Feb

Sayers T.J.; Sowder R.; Wiltrout T.; Wine J.; Henderson L.; Wiltrout R.H.; Smyth M.J., 1991: A cytostatic protein isolated from natural killer cell granules. Journal of Cellular Biochemistry Supplement (15 PART F): 81

Danaher, R.J.; Jacob, R.J.; Chorak, M.D.; Freeman, C.S.; Miller, C.S., 1999: Heat stress activates production of herpes simplex virus type 1 from quiescently infected neurally differentiated PC12 cells. We have previously described a novel in vitro model of a non-productive herpes simplex virus type 1 (HSV-1) infection in neurally differentiated (Nd)-PC12 cells that allows for inducible virus replication upon forskolin treatment. In this study, w...

Prudhomme, A., 2007: From early diagnosis to disability, how to slow the progression of chronic obstructive lung disease?. Soins; la Revue de Reference Infirmiere: 33-35

Sypniewski, R., 2016: Motivational Interviewing: A Practical Intervention for School Nurses to Engage in Trauma Informed Care. This article provides an overview of motivational interviewing (MI) as an effective intervention for trauma informed care. It offers a description of trauma and its most commonly associated negative side effects in the school setting. Within this...

Udell Kent S., 1998: Application of in situ thermal remediation technologies for DNAPL removal. The removal of volatile and semi-volatile contaminants from the heterogeneous domain of the subsurface by in situ thermal technologies is described. Several mechanisms have been identified which account for the remarkable effectiveness of thermal...

Nelson, J.C.; Bowers, M.B., 1978: Delusional unipolar depression: description and drug response. This retrospective study describes the response of 13 delusional unipolar depressives to combination antipsychotic-tricyclic antidepressant drug therapy. The Research Diagnostic Criteria were used by two independent raters to verify the presence o...

van der STRAETEN, 1962: Fungus infection of the lung. Belgisch Tijdschrift Voor Geneeskunde 18: 52-56

Sivarama Sastry, K.; Sarma, P.S., 1957: Behaviour of reductone in ascorbic acid estima-tlon. Current Sci 26(2): 52

Alphs, D.A.; Schank, S.C., 1984: Water tolerance of Pennisetum hybrids. Crosses were made using 3 varieties of americanum as female parent and 10 selections of P. purpureum as male parent. Seedlings were planted in 6 blocks, 5 of which were subjected to an irrigation treatment. The treatment lasted 12 weeks and consis...