+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Proton spectroscopy in the narcoleptic syndrome. Is there evidence of a brainstem lesion?

, : Proton spectroscopy in the narcoleptic syndrome. Is there evidence of a brainstem lesion?. Neurology 50(2 Suppl 1): S23-S26

There is controversy regarding the relationship of structural or biochemical brainstem lesions to 'idiopathic" narcolepsy. Most cases of the narcoleptic syndrome are considered to be idiopathic because no structural lesion is detectable, although some cases of secondary narcolepsy are known to be associated with no structural brainstem lesions. Using proton spectroscopy, we determined levels of ventral pontine metabolite pools in 12 normal subjects and 12 subjects with idiopathic narcolepsy. REM sleep is generated in ventral pontine areas. Proton spectroscopy was used to study levels of N-acetyl aspartate (NAA) as a marker of cell mass, creatine and phosphocreatine (Cr + PCr), and choline (Cho). The intensity of the peaks, as determined by the area under the peak (AUP), was measured. The AUP correlates with the quantity of chemical present. In this study, the ratios of NAA to Cr + PCr were similar in normal subjects and in narcoleptic subjects with idiopathic narcolepsy. No differences in measured metabolic ratio were observed in subjects who slept during the scan procedure compared with those who remained awake. Subjects with 'symptomatic' narcolepsy accompanied by an obvious structural brain lesion were not studied. Proton spectroscopy of the brain initiates a new kind of neurochemistry, allowing the noninvasive study of metabolic pools in the living human brain without the use of any kind of tracer or radioactive molecule. In this study, there was no evidence of cell loss in the ventral pontine areas of subjects with the narcoleptic syndrome.


PMID: 9484419

DOI: 10.1212/WNL.50.2_Suppl_1.S23

Other references

Anonymous, 2001: Corrigendum. Molecular Plant Pathology 2(6): 365-365

Kato, T., 2004: Effect of spikelet removal on the grain filling of Akenohoshi, a rice cultivar with numerous spikelets in a panicle. The Japanese rice cultivar, Akenohoshi, has numerous spikelets in a panicle (extra-heavy panicle type) and achieves a large yield sink capacity. However, this cultivar, as well as other extra-heavy panicle types, does not always produce higher yie...

Prasad, R.; Al-Keraif, A.Abdullah.; Kathuria, N.; Gandhi, P.V.; Bhide, S.V., 2016: Accuracy of ringless casting and accelerated wax-elimination technique: a comparative in vitro study. The purpose of this study was to determine whether the ringless casting and accelerated wax-elimination techniques can be combined to offer a cost-effective, clinically acceptable, and time-saving alternative for fabricating single unit castings i...

Levanon, D.; Brenner, O.; Negreanu, V.; Bettoun, D.; Woolf, E.; Eilam, R.; Lotem, J.; Gat, U.; Otto, F.; Speck, N.; Groner, Y., 2001: Spatial and temporal expression pattern of Runx3 (Aml2) and Runx1 (Aml1) indicates non-redundant functions during mouse embryogenesis. The human RUNX3/AML2 gene belongs to the 'runt domain' family of transcription factors that act as gene expression regulators in major developmental pathways. Here, we describe the expression pattern of Runx3 during mouse embryogenesis c...

Ambrosini, J.Jones.; King, B., 2010: "Swine" flu: a new challenge. Diabetes Self-Management 26(6): 68-71

Jennings, I.; Kitchen, S.; Woods, T.A.; Preston, F.E., 2000: Normalization does not improve between-laboratory agreement but may improve specificity of some assays for activated protein C resistance. Blood Coagulation & Fibrinolysis 10(7): 451-453

Drew, H.J.; Singh, S.M.; Caine, R.L.; Arora, S., 2010: A survey of referral strategies used by periodontal practices in New Jersey. Journal of the New Jersey Dental Association 81(1): 26-28

Rzepka Plevnes, D.; Kulpa, D.; Charkot, S., 2006: Salt tolerance screening of Pinus sylvestris L. from the dunes of the south-west coast of the Baltic sea under in vitro condition. The studies aimed at determining the phenotypic and genetic differences as regards tolerance to saline level observed between pine trees (Pinus sylvestris L.) growing on dunes outside Miqdzyzdroje (Poland). The tolerance to salinity was determined...

Reichard, H., 1964: A Pacifier Holder. Svenska Lakartidningen 61: 597-598

Conejero, L.; Higaki, Y.; Baeza, M.L.; Fernández, M.; Varela-Nieto, I.; Zubeldia, J.M., 2007: Pollen-induced airway inflammation, hyper-responsiveness and apoptosis in a murine model of allergy. Previous studies indicate that murine models are useful tools for studying the allergic diseases, including certain aspects of bronchial asthma such as cellular tissue inflammation and pulmonary function.To develop an experimental model of allerg...