+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Psychosocial modulation of cytokine-induced natural killer cell activity in older adults

, : Psychosocial modulation of cytokine-induced natural killer cell activity in older adults. Psychosomatic Medicine 58(3): 264-272

The objective of this study was to address the cellular and psychological mechanisms underlying previously observed changes in natural killer (NK) cell cytotoxicity associated with chronic stress. We compared 28 current and former spousal caregivers of patients with Alzheimer's disease (AD) and 29 control subjects. NK cells were enriched (E-NK) using a 4-step procedure that resulted in a cell preparation consisting of 88.2% NK cells. These cells were then incubated with either recombinant interferon-gamma (rIFN-gamma) or recombinant interleukin-2 (rIL-2) for 65 hours. Although an average of over 3 years had elapsed since the death of the patient with AD for the former caregivers, current and former caregivers did not differ in the E-NK cell responses to rIFN-gamma and rIL-2. However, the E-NK cell response for the combined caregiver group was significantly suppressed compared with controls, which is consistent with a previous report from our laboratory. Higher E-NK cell responses to each cytokine were associated with heightened levels of positive emotional and tangible social support, independent of levels of depression. Preliminary data suggest that defects of NK cell function in response to rIFN-gamma and rIL-2 as a consequence of caregiver stress may be independent of non-NK cells. Finally, our data are consistent with other studies regarding the role of social support in immune modulation.


PMID: 8771626

DOI: 10.1097/00006842-199605000-00010

Other references

Lloyd S.W.; Tucker C.S., 1988: Comparison of three solvent systems for extraction of chlorophyll a from fish pond phytoplankton communities. Chloroform-methanol (2:1 v/v), absolute methanol, and 90% acetone were evaluated for their effectiveness as extractants of chlorophyll a from samples of phytoplankton communities collected from catfish ponds. Chloroform-methanol consistently extra...

Zhadin V.V., 1984: Space-and-time relationships between strong earthquakes. Physics of the Solid Earth 20(1): 25-28

Hansen, E.L.; Cryan, W.S., 1966: Variation in sex ratio of Panagrellus redivivns in response to nutritional and heat stress. The sex ratio in axenic cultures of P. redlvivus was changed from 1:1 to a high predominance of males by imposing a stress of low protein supplement and high temperature, 28[degree]C. The females developed normally after removal of the stress.

Rossel, S.; Wehner, R., 1984: How bees analyse the polarization pattern in the sky. Experiments and model. From previous work [e.g. see AA 830/84] it is known that honeybees orient by means of a simplified e-vector map when their view of the sky is restricted to single e-vector directions. Nothing is known of how bees analyse the polarization pattern a...

Rane, V.; Patil, K.; Shinde, D., 2009: Enantiomeric LC separation of valsartan on amylose based stationary phase. A simple, rapid and robust LC method was developed and validated for the enantiomeric separation of valsartan in bulk drug and formulation. The enantiomers of valsartan were resolved on a Chiralpak AD-H (amylose based stationary phase) column usin...

Rheinecker, P., 1994: (Catholic Health Association) project identifies core leadership competencies. Health Progress 75(4): 66-7, 75

Shoji, R.; Machida, T.; Kido, A.; Nakamura, K.; Suzuki, R., 1976: A case of malignant melanoma found in the vaginal wall and the urethra. Nihon Hinyokika Gakkai Zasshi. Japanese Journal of Urology 67(8): 663-669

Sudasrip H., 1981: Reversal of arenga pinnata spadices into vegetative shoots and its relevance to the origin of coconut bulbils. Two branching A. pinnata palms standing close to each other in a forest area of Minahasa district of North Sulawesi Province (Indonesia) have aerial shoots (8 in one and 6 in the other) that have developed from modified inflorescences. There is on...

Zaliwski, S., 1962: The influence of pruning on annual bearing and fruit quality in dwarf apple trees. The aim of this experiment was to find out whether pruning young trees and thinning out of the older trees is necessary, and what the influence of these measures on growth and yield of dwarf apple trees is. Trees on EM IX were given pruning treatm...

Sorrel, A.Lynn., 2015: Perfecting the portal. Texas Medicine 110(1): 39-42