geoscience.net logo
+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Radiation and aging: Free radical damage, biological response and possible antioxidant intervention


, : Radiation and aging: Free radical damage, biological response and possible antioxidant intervention. Medical Hypotheses 41(5): 473-482

In this review, the basic processes responsible for radiation-induced changes in critical cell components and their biological consequences will be discussed. The chemical and physical alterations in biomolecules are mediated by free radicals and other reactive intermediates formed, following absorption of radiant energy, by ionization of proximal targets or the surrounding water molecules. Accumulation of free radical damage and its catalysis by various oxidants including quinones and other age pigments, metal ions, lipid peroxides, prostaglandins and components released from cells, increase with age. A cell's response to such damage depends upon environmental and inherited factors. DNA repair is an effective way to protect against radiation damage, but other constitutive or inducible defence mechanisms can also modify biological response, and these processes generally become less effective with age. Loss of fidelity with age of bio-feedback mechanisms including homeostasis, redox control, ion and metabolic regulation, which in turn affects cell growth and differentiation, energy efficiency, the immune system and general health, can be associated with free radical pathology. Current theories of aging will be examined including those involving wear-and-tear, genetic, metabolic, immunologic and biochemical factors. Ionizing radiation, as with other external stresses including UV, heat, chemotherapeutic agents, chemical carcinogens and tumor promoters, interact with nucleic acids, proteins and membrane phospholipids facilitating free radical-mediated oxidative damage. Appropriate antioxidant intervention, by inhibiting or reducing free radical toxicity, may offer protection against radiation, and alleviate or delay symptoms of aging and chronic disease.

US$19.90

PMID: 8145663

DOI: 10.1016/0306-9877(93)90131-9


Other references

Frayha, R.A.; Tabbara, Z.; Berbir, N., 1984: Acute colchicine poisoning presenting as symptomatic hypocalcaemia. Symptomatic hypocalcaemia was the dominant feature of acute colchicine poisoning in a young female with periodic polyserositis. Experimental data suggest that colchicine-induced hypocalcaemia is secondary to colchicine inhibition of bone resorptio...

Brown, K.T.; Brody, L.A.; Decorato, D.R.; Getrajdman, G.I., 2001: Portal vein embolization with use of polyvinyl alcohol particles. Preoperative portal vein embolization has been used as method of inducing compensatory hypertrophy in the future remnant liver since it was first described in the late 1980s. Many different vascular embolic agents have been successfully used for t...

Craig, A., 1983: Co-operative breeding in two African starlings, Sturnidae. Ibis, 1251: 114-115

Page, T.; Moore, G.M.; Will, J.; Halloran, G.M., 2006: Pollen viability in Kunzea pomifera (Myrtaceae) as influenced by sucrose concentration and storage. In vitro germination of freshly collected pollen was examined for five genotypes of Kunzea pomifera in liquid media with 5% and 10% sucrose. There were no significant differences in germination level between the different sucrose concentrations fo...

Bölske, G.; Mörner, T., 1982: Isolation of a Mycoplasma sp. from three buzzards (Buteo spp.). Mycoplasma spp. were isolated from the respiratory tissues of three buzzards. Bird I, a rough-legged buzzard (Buteo lagopus), showed airsacculitis, catarrhal-fibrinous pneumonia, and catarrhal tracheitis. Bird II, a common buzzard (Buteo buteo), r...

Schmidt; Kunze; Shevelko, 1989: Experimental rate coefficients for electron-impact ionization of Ne VI, Ne VII, and Ne VIII. Physical Review. A, General Physics 39(5): 2769-2771

Mann, J.G.; Brown, W.R.; Kern, F., 1970: The subtle and variable clinical expressions of gluten-induced enteropathy (adult celiac disease, nontropical sprue). An analysis of twenty-one consecutive cases. American Journal of Medicine 48(3): 357-366

Essler, W.O.; Folk, G.E., 1960: Monitoring heart rates and body temperatures of unrestrained mammals by radio transmitter. Anat Rec 137(3): 353

Chin, G.S.M.; Warren, N.; Kornman, L.; Cameron, P., 2012: Transferring responsibility and accountability in maternity care: clinicians defining their boundaries of practice in relation to clinical handover. This exploratory study reports on maternity clinicians' perceptions of transfer of their responsibility and accountability for patients in relation to clinical handover with particular focus transfers of care in birth suite. A qualitative stu...

Gillgren, P.; Brattström, G.; Frisell, J.; Palmgren, J.; Ringborg, U.; Hansson, J., 2003: Body site of cutaneous malignant melanoma--a study on patients with hereditary and multiple sporadic tumours. Individuals with an increased risk of developing cutaneous malignant melanoma (CMM) include members of kindreds with hereditary cutaneous malignant melanoma (HCMM) and patients who have already been treated for a CMM. Some of these patients develo...