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Recombinant human serum amyloid A (apoSAAp) binds cholesterol and modulates cholesterol flux


, : Recombinant human serum amyloid A (apoSAAp) binds cholesterol and modulates cholesterol flux. Journal of Lipid Research 36(1): 37-46

During acute inflammation, the serum amyloid A (apoSAA) proteins apoSAA-1 and apoSAA-2 are transiently associated with high density lipoproteins (HDL) in concentrations of as much as 1000-fold more than their concentrations during homeostasis; however, their effect on HDL function is unclear. Recombinant apoSAAP-p, a hybrid of the closely related human apoSAA-1, and apoSAA-2 isoforms, was found to exhibit a high affinity for cholesterol.

US$29.90

PMID: 7706946


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