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Regulation of cytosolic free Ca2+ in cultured rat alveolar macrophages (NR8383)

, : Regulation of cytosolic free Ca2+ in cultured rat alveolar macrophages (NR8383). Journal of Leukocyte Biology 62(3): 341-348

Ca-2+ mobilization in the rat alveolar macrophage cell line NR8383 was examined with the Ca-2+-sensitive fluorescent probe Fura-2. ATP and norepinephrine elicited a 108 and 46% increase, respectively, in cytosolic free Ca-2+ concentration ((Ca-2+)-i). Acetylcholine, nicotine, isoproterenol, substance P, and vasoactive intestinal polypeptide did not alter (Ca-2+)-i. Inositol 1,4,5-trisphosphate (IP-3) formation was also activated by ATP.


PMID: 9307072

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