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Regulation of distinct stages of skeletal muscle differentiation by mitogen-activated protein kinases

, : Regulation of distinct stages of skeletal muscle differentiation by mitogen-activated protein kinases. Science (Washington D C) 278(5341): 1288-1291, Nov 14

The signal transduction pathway or pathways linking extracellular signals to myogenesis are poorly defined. Upon mitogen withdrawal from C2C12 myoblasts, the mitogen-activated protein kinase (MAPK) p42Erk2 is inactivated concomitant with up-regulation of muscle-specific genes. Overexpression of MAPK phosphatase-1 (MKP-1) inhibited p42Erk2 activity and was sufficient to relieve the inhibitory effects of mitogens on muscle-specific gene expression. Later during myogenesis, endogenous expression of MKP-1 decreased. MKP-1 overexpression during differentiation prevented myotube formation despite appropriate expression of myosin heavy chain. This indicates that muscle-specific gene expression is necessary but not sufficient to commit differentiated myocytes to myotubes and suggests a function for the MAPKs during the early and late stages of skeletal muscle differentiation.


PMID: 9360925

DOI: 10.1126/science.278.5341.1288

Other references

Senie R.T.; Rosen P.P.; Rhodes P.; Lesser M.L.; Kinne D.K., 1992: Obesity at diagnosis of breast carcinoma influences duration of disease free survival. Objective: To study disease-free survival at 10 years in relation to obesity at the time of diagnosis. Design: A prospective study of consecutively treated patients with primary breast cancer. Setting: Memorial Sloan-Kettering Cancer Center, New Y...

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Nosen, E.; Nillni, Y.I.; Berenz, E.C.; Schumacher, J.A.; Stasiewicz, P.R.; Coffey, S.F., 2013: Cue-elicited affect and craving: advancement of the conceptualization of craving in co-occurring posttraumatic stress disorder and alcohol dependence. Posttraumatic stress disorder (PTSD) commonly co-occurs with alcohol dependence (AD) and negatively affects treatment outcomes. Trauma-related negative affect enhances substance craving in laboratory cue-reactivity studies of AD individuals, but t...

Krause, T.; Fischer, R.; Barth, I.; Solzbach, U.; Oser, U.; Haag, S.; Rombach, M.; Moser, E., 1996: 3D-fusion image of myocardial perfusion scintigraphy and coronary angiography. Journal of Nuclear Medicine 37(5 SUPPL ): 218P, D.; Nanos, N.; Martens, G.A.; Smet, L.; Damiaens, S.; Van Moer, G.; D.P.uw, A.; Jochmans, K.; D.W.ele, M., 2009: Automated validation of clinical laboratory test results: do we get what we expect?. Clinical Chemistry and Laboratory Medicine 47(3): 379-380

Fischbach, M.; Wolff, P.; Tongio, M.M.; Boudjema, K.; Christmann, D.; Steib, A.; Sauvage, P.; Desprez, P.; Mengus, L.; Simeoni, U., 1994: Five years' experience with quadruple sequential immunosuppression. Transplantation Proceedings 26(1): 17-17

Salihima, A., 1981: Rayon fibres from Anthocephalus cadamba--a semi pilot scale experiment. Berita selulosa 17(4): 90-96

Baumgart, D.C.; Gerl, H.; Dörner, T., 1999: Complete heart block caused by primary Sjögren's syndrome and hypopituitarism. Annals of the Rheumatic Diseases 57(10): 635-635

Kuhn, A.; Neukomm, C.; Dreher, E.F.; Imobersteg, J.; Mueller, M.D., 2014: Prolapse and sexual function 8 years after neovagina according to Shears: a study of 43 cases with Mayer-von Rokitansky-Küster-Hauser syndrome. To investigate sexual and anatomical outcome after Shears neovagina in patients with Mayer-von Rokitansky-Kuster-Hauser syndrome (MRKH). Forty-three consecutive patients with MRKH syndrome underwent surgery creating a neovagina according to Shears...

Chiang, W.; Booren, A.; Strasburg, G., 2008: The effect of heat stress on thyroid hormone response and meat quality in turkeys of two genetic lines. The current study evaluated the effect of heat stress on thyroid hormone (<i>T</i><sub>3</sub> and <i>T</i><sub>4</sub>) response and meat quality traits in two turkey lines: a growth-selected commer...