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Release of 5-fluorouracil from poly(acrylamide-co-monopropyl itaconate) hydrogels

, : Release of 5-fluorouracil from poly(acrylamide-co-monopropyl itaconate) hydrogels. Journal of Chromatography B Biomedical Applications 680(1-2): 243-253

The aim of this work was to test the application of copolymeric poly(acrylamide-co-monopropyl itaconate) (A-MPI) hydrogels on the release of 5-fluorouracil (5-FU). The equilibrium degree of swelling in saline solution was 83 +- 2%. 5-FU, as the sodium salt, was trapped in gels by placing it in the polymerization feed mixture. The diffusion coefficients for both swelling of the gels and the release of 5-FU were determined, in addition to the activation energies for both processes. To determine the applicability of these copolymers, A-MPI (75:25) gel was subcutaneously implanted in rats and the drug plasma concentration was determined by HPLC.


PMID: 8798904

DOI: 10.1016/0378-4347(95)00401-7

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