geoscience.net logo
+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Release of 5-fluorouracil from poly(acrylamide-co-monopropyl itaconate) hydrogels


, : Release of 5-fluorouracil from poly(acrylamide-co-monopropyl itaconate) hydrogels. Journal of Chromatography B Biomedical Applications 680(1-2): 243-253

The aim of this work was to test the application of copolymeric poly(acrylamide-co-monopropyl itaconate) (A-MPI) hydrogels on the release of 5-fluorouracil (5-FU). The equilibrium degree of swelling in saline solution was 83 +- 2%. 5-FU, as the sodium salt, was trapped in gels by placing it in the polymerization feed mixture. The diffusion coefficients for both swelling of the gels and the release of 5-FU were determined, in addition to the activation energies for both processes. To determine the applicability of these copolymers, A-MPI (75:25) gel was subcutaneously implanted in rats and the drug plasma concentration was determined by HPLC.

US$19.90

PMID: 8798904

DOI: 10.1016/0378-4347(95)00401-7


Other references

Chiu, E.K.W.; Yuen, K.; Lie, A.K.W.; Liang, R.; Lau, Y.L.; Lee, A.C.W.; Kwong, Y.L.; Wong, S.; Ng, M.H.; Chan, T.K., 1994: A prospective study of symptomatic bacteremia following platelet transfusion and of its management. Background: The danger of bacteremia due to contaminated platelets is not well known. There are also no established guidelines for the management of febrile reactions after platelet transfusion. Study Design and Methods: To determine the risk of s...

Weintraub, S., 1965: The foreign exchange gap of the developing countries. The share of the underdeveloped countries in world trade has fallen persistently, from 31.3 per cent. in 1953 to 24 per cent. in 1963. From 1950 to 1962 exports from developed countries with market economies rose by 150 per cent. and from communis...

Allen, J.R.; Wilkinson, S.B.; Hawkins, S.J., 1995: Redeveloped docks as artificial lagoons: the development of brackish-water communities and potential for conservation of lagoonal species. Aquatic Conservation. December; 54: 299-309

von der Haar, F., 1992: Management of intensive-care therapy. Artificial Organs 16(2): 203-205

Bethmann, W., 1969: Birth order and cheilo-gnatho-palato-schisis. Cleft Palate Journal 6: 205-209

Brown, L.J.; Beazoglou, T.; Heffley, D., 1994: Estimated savings in U.S. dental expenditures, 1979-89. The American public saved more than $39 billion (1990 dollars) in dental expenditures from 1979 through 1989 in contrast to the substantial increases in expenditures in other sectors of the U.S. health care system that have pushed the system to th...

Paranchych, W.; Sastry, P.A.; Drake, D.; Pearlstone, J.R.; Smillie, L.B., 1985: Pseudomonas pili. Studies on antigenic determinants and mammalian cell receptors. P. aeruginosa PAK pili are thin 5.2 nm diameter filaments containing a single 15-kd polypeptide subunit which is 144 amino acid residues in length. Studies on pili binding to a variety of synthetic sugars representing many di- tri- and tetra-sacch...

Bunyaratavej, K.; Khaoroptham, S.; Phonprasert, C.; Tanboon, J.; Shuangshoti, S., 2005: Primary intracranial peripheral primitive neuroectodermal tumor/Ewing's sarcoma presenting with acute intracerebral hemorrhage. To report two cases of intracerebral hemorrhage due to primary intracranial peripheral primitive neuroectodermal tumor (pPNET)/Ewing's sarcoma (ES) and review of related literatures. Two cases of 17-year-old patients presented with acute incr...

Elliot J.; Platt J.R.; Racine R.J., 1987: Adjustment of successive and simultaneous intervals by musically experienced and inexperienced subjects. A single-stimulus adjustment technique was used to test the accuracy with which musically experienced and inexperienced subjects could intone musical intervals. We were particularly interested in the relationship between any improved accuracy resu...

Schalén, L.; Henriksson, N.G.; Pyykkö, I., 1982: Quantification of tracking eye movements in patients with neurological disorders. Tracking eye movements were studied in 20 healthy subjects and in 24 patients with vestibular neuronitis, disorders within the frontal cortex, the cerebellum or the brain stem. The tracking tests were performed at six different target velocities b...