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Response of the primary lesion in gastric cancer to chemotherapeutic trials


, : Response of the primary lesion in gastric cancer to chemotherapeutic trials. International Journal of Clinical Oncology 3(1): 3-6, Feb

Background: We wish to clarify some points in the evaluation of primary tumors in gastric cancer trials, particularly the response rate and patient survival. Methods: This study includes 226 patients with advanced gastric cancer who had no prior treatment except surgery, and who had been enrolled into 1 of 4 Japan Clinical Oncology Group trials. The regimens for these 226 patients were tegafur and mitomycin C in 50, a combination of tegafur and uracil and mitomycin C in 39, 5'-deoxy-5-fluorouridine and cisplatin in 49, etoposide, doxorubicin, and cisplatin in 42, and 5-fluorouracil and cisplatin in 46 patients. Antitumor responses were evaluated by the Japanese evaluation criteria. Results: Of the 226 patients, 192 (85%) had primary cancers. Only 57 of 192 had roentgenographically measurable tumors. The response rate of the primary cancers was significantly lower than that of measurable metastatic lesions (P < 0.01). Forty-five overall responders who had both primary and metastatic tumors were divided into 31 responders and 14 nonresponders, with reference to primary cancers. The 31 patients who had a response in the primary cancer lived significantly longer (P< 0.05) than the 14 nonresponders, even though there was no significant difference in patient backgrounds between the 2 groups. This difference in survival became even more remarkable after 1 year. Conclusions: Although some questions remain unresolved, evaluation of primary cancer can be meaningful, and the response of primary cancers may be an indicator for long-term survival.

US$19.90

DOI: 10.1007/bf02490094


Other references

Prat, Henri, 1956: Regulation of thermogenesis in the American cockroach Periplaneta americana ; effects of olfactory excitation; influence of decapitation. Calvet micro-calorimeters and continuous recording devices showed that thermogenesis on a maintenance level, ranged between 0.8 and 1.8 calories per hour per gram of liver weight at 31[degree] C. Without any external stimulation, the thermogram di...

Holland, A.; Duivenvoorden, L.J.; Kinnear, S.H.W., 2015: Humic substances of varying types increase survivorship of the freshwater shrimp Caridina sp. D to acid mine drainage. Differences relating to the ability of various types of humic substances (HS) to influence toxicity of pollutants have been reported in the literature, but there still remains a gap in understanding whether various HS will have the same influence...

Fleming, L.W.; Duerksen, J.D., 1967: Evidence for multiple molecular forms of yeast beta-glucosidase in a hybrid yeast. A mixture of beta-glucosidases from Saccharomyces fragilis (Y-18) and S. dobzhanskii (Y-19) eluted from diethylaminoethyl cellulose in two peaks, whereas the enzyme from a hybrid, S. fragilis x S. dobzhanskii (Y-42), eluted in a single broad peak....

Serio, R.; Bonvissuto, F.; Mulè, F., 2001: Altered electrical activity in colonic smooth muscle cells from dystrophic (mdx) mice. Because the colon from dystrophic (mdx) mice shows an altered motor pattern, probably due to neural disorders, our aim was to examine the electrophysiological properties of muscle cells and the functionality of nitrergic transmission in circular m...

Smith, AP., 1977: Observations of birds in Brunei. Sarawak Museum Journal, 46: 235-269

Green, W.R., 1983: The specificity of H-2-restricted cytotoxic T lymphocytes directed to AKR/Gross leukemia virus-induced tumors. I. Isolation of a selectively resistant variant tumor subclone. The AKR.H-2bSL1 tumor cell line is susceptible to H-2Kb-restricted cytotoxic T lymphocytes (CTL) directed against the subclass of AKR endogenous leukemia virus-induced tumors that express the Gross cell surface antigen (anti-AKR/Gross virus CTL)....

Cordeiro, E.; Gervais, M-Kim.; Shah, P.S.; Look Hong, N.J.; Wright, F.C., 2016: Sentinel Lymph Node Biopsy in Thin Cutaneous Melanoma: A Systematic Review and Meta-Analysis. Most patients with melanoma have a thin (≤1.00 mm) lesion. There is uncertainty as to which patients with thin melanoma should undergo sentinel lymph node (SN) biopsy. We sought to quantify the proportion of SN metastases in patients with thin...

Curtis, E., 1994: Contact with the world and to the point. Contact Point celebrates 70 years. Contact Point 74(2): 10-14

Landon, M.B., 2016: In Reply. Obstetrics and Gynecology 127(5): 964-964

Mallbris, L.; Nickoloff, B.J., 2015: Psoriasis: The Poster Child for Bench-to-bedside Translational Medicine. As the largest and most visible organ, the skin provides opportunities to investigate immune responses in clinical studies offering insights that extend beyond our protective coat. The interplay between bench-to-bedside approaches are complemented...