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Risk factors for sensorineural hearing loss in extremely premature infants

, : Risk factors for sensorineural hearing loss in extremely premature infants. Journal of Paediatrics & Child Health 31(4): 312-316

Objective: To identify potentially preventable risk factors for sensorineural hearing loss (SNHL) in extremely premature infants. Methodology: A case control study of survivors with gestational age (GA) lt 28 weeks or birthweight (BW) lt 1000 g using data collected prospectively in our Neonatal Intensive Care Unit database. Each subject with bilateral SNHL gt 40 dB was matched according to GA, BW and sex with two controls who had neither sensorineural nor conductive hearing loss, Results: Infants with SNHL had increased mean (+- s.d.) days ventilated (53 +- 21 vs 37 +- 23 days, P = 0.006) and in oxygen (107+-44 vs 69+-28 days, P = 0.02) compared with controls.The risk for SNHL was increased for infants who spent gt 90 days in oxygen (OR 4.0 (95% Cl 1.1-15.61), had maximum FiO-2 gt 0.90 (5.6 (1.2-26.91), minimum plasma Na lt 125 mmol/L (5.6 (1.1-27.8) or maximum Ph gt 7.60 (5.6 (1.1-89.0)). Neither maximum serum bilirubin nor exposure to ototoxic drugs was associated with SNHL. Conclusions: Avoidance of severe hyponatremia and extreme alkalosis, as well as use of surfactant to minimize the severity of hyaline membrane disease, may result in a decreased incidence of SNHL in extremely premature infants.


PMID: 7576889

DOI: 10.1111/j.1440-1754.1995.tb00818.x

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