geoscience.net logo
+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Role of cytokines in the modulation of neutrophil chemotaxis in localized juvenile periodontitis


, : Role of cytokines in the modulation of neutrophil chemotaxis in localized juvenile periodontitis. Journal of Periodontal Research 29(2): 127-137

Decreased neutrophil chemotaxis has been implicated in the pathophysiology of the disease, localized juvenile periodontitis (LJP). The biological basis for the altered neutrophil function in LJP has been suggested to be an intrinsic cellular defect, involving a decrease in the number of N-formyl-methionyl-leucyl-phenylalanine (FMLP) receptors on the cell surface. We have investigated the relative contribution of serum-borne factors in the modulation of neutrophil functions in LJP, in a large population of LJP patients and healthy control subjects (HS). Treatment of HS-neutrophils with LJP-sera, resulted in a decreased neutrophil chemotactic response, and down regulation of FMLP receptors on the cell surface. Pretreatment of LJP-sera with antiTNF and anti-IL-1 antibodies effectively, although incompletely, neutralized the ability of LJP-sera to modulate chemotaxis and FMLP receptor levels in HS-neutrophils. The changes induced by LJP sera were specific and sustained and could not be reversed by placing LJP-serum treated neutrophils in HS-serum. Sera obtained from HS and patients with adult periodontitis (AP), both of which exhibit normal chemotaxis, and patients with clinically diagnosed LJP with normal neutrophil chemotaxis (LJP-nctx) did not modulate HS neutrophil chemotaxis or FMLP receptors. Furthermore, recombinant human TNF-alpha, rhIL-1-alpha and rhIL-1-beta, at very low concentrations (15 pg/ml to 150 pg/ml), modulated the chemotactic response as well as FMLP receptor numbers on HS-neutrophils, in a manner similar to those observed in LJP. The present findings demonstrate that the biologic basis for the altered neutrophil function may not be an intrinsic cellular defect in neutrophils, but at least in part due to quantitatively small but biologically significant elevations in the levels of TNF-alpha and IL-1 in the serum.

US$19.90

PMID: 8158501

DOI: 10.1111/j.1600-0765.1994.tb01101.x


Other references

Rojas D., 1970: Development of the structures situated at the basis of the ovarioles during the egg laying period in acheta domesticus orthoptera gryllidae. Bulletin de la Societe Zoologique de France 95(4): 687-697

Kerksick, C.M.; Roberts, M.D.; Dalbo, V.J.; Sunderland, K.L., 2016: Intramuscular phosphagen status and the relationship to muscle performance across the age spectrum. To examine age-related differences in intramuscular concentrations of adenosine triphosphate (ATP), free creatine (FCr), phosphocreatine (PCr) and total creatine (TCr) and if these differences were related to muscle performance. Forty-two healthy,...

Shen, L.; Chiang, A.K.; Liu, W.P.; Li, G.D.; Liang, R.H.; Srivastava, G., 2001: Expression of HLA class I, beta(2)-microglobulin, TAP1 and IL-10 in Epstein-Barr virus-associated nasal NK/T-cell lymphoma: Implications for tumor immune escape mechanism. Several mechanisms of immune escape might be in operation in Epstein-Barr virus (EBV)-associated nasal NK/T-cell lymphoma. We have previously shown the downregulation of the immunogenic EBV nuclear antigens by alternative promoter usage and the pr...

Hancocks, S., 1997: Tinker, tailor, soldier, dentist. British Dental Journal 183(2): 77-77

Maigaard, S.; Frimodt-Möller, N.; Hoyme, U.; Madsen, P.O., 1979: Rosoxacin and cinoxacin distribution in prostate, vagina, and female urethra. An experimental study in dogs. Rosoxacin and cinoxacin, two new compounds structurally related to nalidixic acid, were investigated in dogs. Our primary interest was in the beneficial effects of the two drugs when used in the treatment of urinary tract infections. The distribut...

Krishnan, S., 2015: MTP Amendment Bill, 2014: towards re-imagining abortion care. In India, the 1971 Medical Termination of Pregnancy Act, while allowing abortions under a broad range of circumstances, can be considered a conservative law from a feminist perspective. The Act allows healthcare providers rather than women seeking...

Oleinik I.I.; Rodionova S.N.; Bychkov V.A.; Sakharova A.E., 1978: Use of the indirect hem agglutination test to detect pseudomonas aeruginosa antibodies in patients with acute purulent destructive pneumonia. Zhurnal Mikrobiologii Epidemiologii i Immunobiologii (9): 70-74

Chen, F.; Duan, H.; Zhang, Y.; Wu, Y-Hua., 2016: Effect and mechanism of formation of intrauterine adhesion at different dose of estrogen. To investigate the effect and mechanism of the formation of intrauterine adhesion (IUA) at different dose of estrogen. Thirty-three New Zealand female rabbits were randomly divided into low estrogen group, normal physiological estrogen group, mode...

Porena, M.; Virgili, G.; Lombi, R.; Micheli, C.; Mearini, E., 1983: Vaginal metastasis from unsuspected renal cell carcinoma. The Authors report on a case of renal cell carcinoma with vaginal metastasis, which appeared on clinical examination as a primary vaginal disease without urinary symptoms.

Eloranta E., 1989: Computational geophysics and modeling problems. Geologi 41(1): 6-9