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Role of intestinal epithelial cells in the host secretory response to infection by invasive bacteria. Bacterial entry induces epithelial prostaglandin h synthase-2 expression and prostaglandin E2 and F2alpha production


, : Role of intestinal epithelial cells in the host secretory response to infection by invasive bacteria. Bacterial entry induces epithelial prostaglandin h synthase-2 expression and prostaglandin E2 and F2alpha production. Journal of Clinical Investigation 100(2): 296-309

Increased intestinal fluid secretion is a protective host response after enteric infection with invasive bacteria that is initiated within hours after infection, and is mediated by prostaglandin H synthase (PGHS) products in animal models of infection. Intestinal epithelial cells are the first host cells to become infected with invasive bacteria, which enter and pass through these cells to initiate mucosal, and ultimately systemic, infection. The present studies characterized the role of intestinal epithelial cells in the host secretory response after infection with invasive bacteria. Infection of cultured human intestinal epithelial cell lines with invasive bacteria, but not noninvasive bacteria, is shown to induce the expression of one of the rate-limiting enzymes for prostaglandin formation, PGHS-2, and the production of PGE-2 and PGF-2alpha. Furthermore, increased PGHS-2 expression was observed in intestinal epithelial cells in vivo after infection with invasive bacteria, using a human intestinal xenograft model in SCID mice. In support of the physiologic importance of epithelial PGHS-2 expression, supernatants from bacteria-infected intestinal epithelial cells were shown to increase chloride secretion in an in vitro model using polarized epithelial cells, and this activity was accounted for by PGE-2. These studies define a novel autocrine/paracrine function of mediators produced by intestinal epithelial cells in the rapid induction of increased fluid secretion in response to intestinal infection with invasive bacteria.

US$19.90

PMID: 9218506

DOI: 10.1172/JCI119535


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Basto, Maria Fernanda Pinto, 2002: Salicaceae. This seven-page book is part of a series on vascular plants of Cape Verde and reviews members of the family Saliaceae. The text is written in Portuguese and describes the anatomy, habitat, and distribution. The anatomy and nomenclatural informatio...

Hudson, R.J.; Thomson, I.R., 1995: Pro: The choice of muscle relaxants is important in cardiac surgery. Journal of Cardiothoracic and Vascular Anesthesia 9(6): 768-771

E.M.wafy, A.M.; Abou Zeid, L.A., 2006: Resveratrol activates the kinase-G system in human coronary smooth muscle cells via a nongenomic, estrogen-independent mechanism. Resveratrol (RSVL), a polyphenolic phytoestrogen in grapes, confers multifaceted cardiovascular benefits. The cellular and molecular basis of RSVL actions has been largely undefined. Currently, in human coronary smooth muscle cells (HCSMCs), RSVL...

Issekutz, A.C.; Ripley, M.; Jackson, J.R., 1983: Role of neutrophils in the deposition of platelets during acute inflammation. Platelets can release a variety of inflammatory mediators. These formed elements have been shown to accumulate early in acute inflammation, often prior to fibrin and thrombus formation. Polymorphonuclear leukocyte (PMNL) infiltration is also an ea...

Springett M.W., 1986: Practical approaches to geologic modeling in precious metals reserve estimation. Pages 113-120 1986

Fujioka, T.; Hasegawa, M.; Ogiu, K.; Matsushita, Y.; Sato, M.; Kubo, T., 1996: Antitumor effects of angiogenesis inhibitor O- fumagillol against murine renal cell carcinoma. Purpose: The effect of 0-(chloroacetyl-carbamoyl) fumagillol (TNP-470) on tumor growth and metastasis is investigated. Materials and Methods: BALB/c mice were inoculated with the Renca murine tumor and graded doses of TNP-470 were given subcutaneo...

Nunes,P.A.L.D.; Silvestri,S.; Pellizzato,M.; Boatto,V., 2008: Regulation of the fishing activities in the lagoon of Venice, Italy results from a socio-economic study. In the last years, the overall fish industry in the lagoon of Venice has shown a gradual decline. In order to better understand this process, we carry out a socio-economic questionnaire next to the fisherman population. Questionnaire contains sign...

Carter, C.E.; Ix, J.H., 2015: Urinary creatinine and survival in CKD. Clinical Journal of the American Society of Nephrology 9(12): 2028-2029

Lehmann-Nitsche, R., 1928: Las aves en el folklore Sudamericano. Hornero Buenos Aires, 4: 166-173

Farrer-Brown, G.; Tarbit, M.H.; Somers, K.; Hutt, M.S., 1972: Microvascular study of hearts with endomyocardial fibrosis. British Heart Journal 34(12): 1250-1262