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Role of plasminogen activator inhibitor type 1 in the pathogenesis of coronary artery diseases

, : Role of plasminogen activator inhibitor type 1 in the pathogenesis of coronary artery diseases. Haemostasis 24(4): 243-251

Patients with ischaemic heart disease have high levels of plasminogen activator inhibitor type 1 (PAI-1). These levels can constitute an independent thrombotic risk factor. In addition, PAI-1 synthesis is greater in the atherosclerotic vessels than in the normal vessels and this can also constitute an atherogenic risk factor. There is a good correlation between insulinaemia and PAI-1, but it has not been demonstrated that the circulating level of PAI-1 depends exclusively on insulinaemia.


PMID: 7988952

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