geoscience.net logo
+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Segregation analysis of pulmonary function among families in the Framingham Study


, : Segregation analysis of pulmonary function among families in the Framingham Study. American Journal of Respiratory and Critical Care Medicine 157(5 Pt 1): 1445-1451

Familial aggregation of cross-sectional pulmonary function was examined in 5,003 subjects from 1,408 families participating in the Framingham Study. Subjects, who were members of either the Original Cohort (recruited from 1948 to 1952) or the Offspring Cohort (recruited from 1971 to 1974), underwent spirometry at a mean age of 53 yr. The effects of age, height, weight, and smoking status on FEV1 were evaluated through linear-regression analysis, with separate models for men and women in each cohort. The gender- and cohort-specific standardized residual FEV1 from these models was used as the phenotypic variable in familial correlation and segregation analyses to assess inheritance patterns. In models that assumed no major gene determining FEV1, correlation of pulmonary function was greater for mothers and offspring than for fathers and offspring (rho(mo) = 0.190, rho(fo) = 0.112; p = 0.06), and sibling correlation exceeded parent-offspring correlation (rho(sib) = 0.225; p < 0.01). By comparison with a general model, in which transmission probabilities and residual familial correlations are arbitrary, models that imposed a Mendelian gene were rejected (p < 0.001). A model with no parent-offspring transmission of a major factor, but with residual familial correlation, provided as good a fit as the general model, suggesting that environmental and/or polygenic genetic influences determine FEV1.

US$19.90

PMID: 9603122

DOI: 10.1164/ajrccm.157.5.9704021


Other references

Anonymous, 2010: Modifications to S3 report. Joint Commission Perspectives. Joint Commission on Accreditation of Healthcare Organizations 30(7): 11-11

Sharma A.K.; Pant C.C., 1988: Ichnogenus skolithos from gethia unit district nainital kumaun lesser himalaya india. Current Science (Bangalore) 57(14): 800-802

Kvistberg, David Robert, 1964: Model studies on the staining reaction of beta cells of the islets of Langerhans by aldehyde fuchsin. Diss Abstr 25(5): 2762-2763

Zeuthen, J.; Bak, P.; Bak, A.L., 1979: Chromosomal unit fibers in Drosophila. Chromosomal unit fibers consisting of long, regular fibers of about 0.40 micron diameter were obtained from disintegrated, isolated chromosomes of two Drosophila melanogaster cell lines. In one cell line with an essentially normal karyotype, three...

Gilbert, A.M.; Mewshaw, R.E., 2002: N-aryl- -cyclohexyl amines. This invention provides novel compounds and methods and compositions using them in the treatment of central nervous system disorders, including depression and anxiety, the compounds having the formula: ##STR1## wherein Ar is an aryl group of 4 to...

Schapira, D.; Lorber, M., 1988: Reiter's syndrome following recurrent gonococcal urethritis. Incomplete Reiter's syndrome followed recurrent gonococcal urethritis in a 36-year-old man. While gonococcal arthritis is a most common type of septic arthritis, the role of Neisseria gonorrhoeae in reactive arthritis, such as Reiter's s...

Zhang Xi, 1995: Fibre and paper-making properties of the main bamboo species in Guizhou. The fibre and paper-making properties of 22 bamboos species are described.

Shir, Y., 1989: Intrathecal Opioids, Potency and Lipophilicity. Pain 38(2): 235-236

Tsanev, K.; Lazarov, I.Onopisov, R., 1963: Apropos Of Malignant Melanomas Of The Rectum. Khirurgiia 16: 969-974

Blecker, D.L., 2000: Medicare's evaluation and management codes. New Jersey Medicine 97(6): 35-37