+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Serum bicarbonate is an independent determinant of protein catabolic rate in chronic hemodialysis

, : Serum bicarbonate is an independent determinant of protein catabolic rate in chronic hemodialysis. American Journal of Nephrology 16(5): 382-385

Serum bicarbonate is an independent determinant of protein catabolic rate in chronic hemodialysis. Recent biochemical studies suggest that metabolic acidosis induces an increase in protein catabolic rate. Therefore, we retrospectively examined the relationship between serum total CO2, normalized protein catabolic rate (NPCR), midweek BUN, KT/V, and serum albumin in 70 chronic hemodialysis patients over a period of 4-6 months (total of 270 determinations). Multiple regression analysis indicated an independent and inverse association of tCO2 with NPCR (p < 0.0001). Subsequent analysis of the data indicated a nonlinear relationship between serum CO2 and NPCR. Indeed, the slope of the regression abruptly increased from -0.015 +/- 0.005 to -0.108 +/- 0.032 when analyzed for serum CO2 < or = 15 mEq/l. We conclude that metabolic acidosis may modulate protein kinetics in patients receiving maintenance hemodialysis. Moreover, this relationship appears to be exaggerated at moderate to severe reductions in tCO2. Thus, this analysis suggests that decreases in tCO2 have a detrimental effect on protein catabolism in stable patients maintained on chronic hemodialysis.


PMID: 8886174

Other references

Vorobiev, A.I., 1958: Medical services for jet airliner passengers in the USSR. Journal of Aviation Medicine 29(11): 785-786

Cooper M.D., 1978: Generation of bone marrow derived cells. Federation Proceedings 37(6): 1674

Moon, S-Hee.; Cho, S.; Park, K-Min., 2014: Crystal structure of catena-poly[[silver(I)-μ-N-(pyridin-2-ylmeth-yl)pyridine-3-amine-κ(2) N:N'] tri-fluoro-methane-sulfonate. In the asymmetric unit of the title compound, {[Ag(C11H11N3)]CF3SO3} n , there are two Ag(I) atoms, two N-(pyridine-2-ylmeth-yl)pyridine-3-amine ligands (A and B) and two CF3SO3 (-) anions. Both Ag(I) atoms are bridged by two pyridine N atoms from...

Silva Filho, F.S., 1950: Laboratory tests for the control of class A pasteurized milk. Laboratory tests considered indispensable are the total bacterial count, presumptive coliform test and the phosphatase test; results of applying the former tests to 893 samples of class "A" pasteurized milk in Sao Paulo during December 1...

Mackowsky Marie Therese, 1984: Report on the activities of the ICCP. 1: 74-75 1984

Mohapatra, P.R.; Punatar, S., 2012: The battle against cancer: UID-linked cancer registry should replace existing registry in India. National Medical Journal of India 24(6): 377-377

Werneck, F.L., 1952: ContribuiYao ao conhecimento dos Anopluros. I-III. Revista Brasileira de Biologia, 12: 69-78

Luo JinRen, 2005: Outline of models for returning farmland to grass in different areas and of zoning for grass cultivation. The general targets for returning cultivated farmland to grassland and woodland will reach 686 700, 745 300 and 745 300 ha by the years 2010, 2020 and 2050, respectively, in Gansu, China. Meanwhile, the 15.1 million ha of steppes also have to be w...

Rusin A.I.; Krasnobayev A.A., 1992: Nature of the Precambrian in the Phanerozoic fold regions. Pages 17-28 1992

Kawasaki H.; Utsuyama M.; Takahashi H.; Hayashi Y.; Kurashima C.; Esaki Y.; Maruyama N.; Hirokawa K., 1989: Establishment of a monoclonal antibody against senile plaques and its application for immunohistological and immunoelectron microscopical studies in the brain of the elderly. A monoclonal antibody (Am-3) was produced against senile plaques in the brain of a patient with Alzheimer's disease. Am-3 was reactive with senile plaques of typical, primitive and diffuse type not only in the brain used as immunogen, but als...