+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Sexually dimorphic response of the balloon-injured rat carotid artery to hormone treatment

, : Sexually dimorphic response of the balloon-injured rat carotid artery to hormone treatment. Circulation 95(5): 1301-1307

Background. Estrogen blunts the neointimal response to vascular injury in gonadectomized rats of both sexes; addition of a progestin blocks the estrogen effect. This study tested, in intact rats of both sexes, whether (1) exogenous estrogen has a vasoprotective effect in injured carotid arteries, (2) progestin (medroxyprogesterone acetate, MPA) blocks the vasoprotective effect of estrogen, and (3) any observed sexual dimorphism in the responses to estrogen and/or MPA can be accounted for by differences in serum 17-beta-estradiol levels. Methods and Results. Intact male and female Sprague-Dawley rats were randomly divided into four subgroups treated with either (1) 17-beta-estradiol, (2) MPA, (3) 17-beta-estradiol+MPA, or (4) vehicle and were subjected to balloon injury of the right common carotid artery. Two weeks later, rats were killed by an overdose of pentobarbital, and the carotid arteries were evaluated for myointimal thickening. Neither estradiol nor MPA altered the neointimal response in males. In females, estradiol reduced and MPA enhanced the response, whereas addition of MPA to estradiol blocked the vasoprotective effects of estrogen. Conclusions. Intact male rats but not intact females are resistant to the vasoprotective effects of exogenous estrogen, despite attainment of physiological (for females) serum 17-beta-estradiol levels. MPA enhances the neointimal response in intact females, presumably by blocking the production and thus the vasoprotective effect of endogenous estrogen.


PMID: 9054863

Other references

Sainte Marie B.; Hargrave B.T., 1987: Estimation of scavenger abundance and distance of attraction to bait. Patterns of arrival, times of first arrival on bait, and instantaneous numbers of animals on bait may be used to estimate abundance and distance of attraction for scavenging species of fish and invertebrates. A simple Gaussian odour plume model, w...

Vassella, E.; Den Abbeele, J.V.; Bütikofer, P.; Renggli, C.K.; Furger, A.; Brun, R.; Roditi, I., 2000: A major surface glycoprotein of trypanosoma brucei is expressed transiently during development and can be regulated post-transcriptionally by glycerol or hypoxia. Differentiation is a means by which unicellular parasites adapt to different environments. In some cases, the developmental program may be modulated by interactions with the host, but the mechanisms are largely unknown. Trypanosoma brucei is trans...

Gold, R.L.; Katz, R.J.; Bren, G.B.; Varghese, P.J.; Ross, A.M., 1985: Treatment of sinus node reentrant tachycardia with verapamil. American Heart Journal 109(5 Pt 1): 1104-1108

Steinhagen-Thiessen, E.; Hamel, G.; Lüttje, D.; Oster, P.; Plate, A.; Vogel, W., 2003: Geriatrics-quo vadis? The system of geriatric care. The authors describe the current and perspective structure of geriatric care in hospital and rehabilitation units. First the specific needs of elderly patients with various medical problems (multiple morbidity) are described. Furthermore the artic...

Piltcher, M.L., 1964: Acetonyl Triamcinolone And Periarthritis Of The Shoulder. Hospital 65: 1031-1049

Mutch, N., 1949: Antipeptic antacid therapy with special reference to adsorbent complexes of calcium and magnesium phosphates. The available therapeutic procedures for diminishing gastric acidity, and experiments on the adsorption of pepsin and basic dyes by " complexes " of silica with calcium and magnesium phosphates, and on the interaction of these and other...

Campos, C.Zago.; Losi Guembarovski, R.; de Oliveira, C.Eduardo.Coral.; Banin Hirata, B.Karina.; Vitiello, G.Akelinghton.Freire.; Dias, Fávia.Luísa.; Hiroki, C.Hiroji.; Watanabe, M.Angelica.Ehara.; Mazzuco, Tânia.Longo., 2017: Glutathione S-transferases deletions may act as prognosis and therapeutic markers in breast cancer. Breast cancer (BC) is the main worldwide neoplasia in women. The metabolic balance between xenobiotic absorption and elimination rates plays an important role in preventing DNA damage and, consequently, tumor development. The glutathione S-transfe...

Zemkova, H.; Tomić, M.; Kucka, M.; Aguilera, G.; Stojilkovic, S.S., 2016: Spontaneous and CRH-Induced Excitability and Calcium Signaling in Mice Corticotrophs Involves Sodium, Calcium, and Cation-Conducting Channels. Transgenic mice expressing the tdimer2(12) form of Discosoma red fluorescent protein under control of the proopiomelanocortin gene's regulatory elements are a useful model for studying corticotrophs. Using these mice, we studied the ion chann...

Locatelli D.P.; Galli A., 1985: The influence of diet on wing development in psyllipsocus ramburi selys longchamps psocoptera trogiomorpha. The paper describes the studies performed to clarify the relationships that eixst, between the wings development and diet of the P. ramburi, which commonly exists in a micropterous form. Laboratory tests, which has been performed giving food consi...

Sperling R.I.; Benincaso A.I.; Austen K.F.; Anderson R.; Coblyn J.; Weinblatt M.E., 1990: Effects of methotrexate therapy on 5 lipoxygenase pathway metabolism of arachidonic acid in rheumatoid arthritis. Arthritis & Rheumatism 33(9 SUPPL): S38