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Short-term efficacy of domestic gliclazide against noninsulin-dependent diabetes mellitus in 112 patients


, : Short-term efficacy of domestic gliclazide against noninsulin-dependent diabetes mellitus in 112 patients. Zhongguo Yiyao Gongye Zazhi 28(1): 23-26

Domestic gliclazid (1) was used to treat 112 patients with noninsulin-dependent diabetes mellitus (NIDDM). The other 93 were treated with imported product (2) as control. The daily oral dose of 1 ranged from 20 to 240 (111.1 +- 64.8) mg. After 2-3 months of treatment, mean fasting and 2-h postprandial blood glucose, plasma fibrinogen, urine glucose excretion and glucohemoglobin levels reduced significantly, glucose tolerance was elevated, serum insulin levels in fasting and after glucose loading increased appreciably, disorder of lipid metabolism was improved in 1 group. The effective dose of 1 was lower than that of 2. The efficacy and bioavailability of 1 were higher than that of 2.

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