geoscience.net logo
+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Sleep-disordered breathing in amyotrophic lateral sclerosis


, : Sleep-disordered breathing in amyotrophic lateral sclerosis. Chest 110(3): 664-669

Objective: The purpose of this study was to assess sleep and breathing in patients with amyotrophic lateral sclerosis (ALS) with bulbar muscle involvement. Design: Prospective, controlled study of sleep and breathing measured during polysomnography. Setting: University teaching hospital and referral center. Patients: Patients with definite ALS and healthy age-matched control subjects. Interventions: Eighteen ALS patients and 10 age-matched control subjects underwent one night of polysomnography. Thirteen patients with ALS were studied for a second night. Results: The ALS patients had more arousals per hour (p=0.008), more stage 1 sleep (p=0.01), and a shorter total sleep time (TST) (279+-69 vs 331.4+-55.9 min, mean-SD, p=0.04) than the control subjects. The ALS patients had mild sleep-disordered breathing with a greater apnea/hypopnea index (AHI) than the control subjects (p=0.005). On the second night of polysomnography there was an increase in TST (p=0.003) and rapid eve movement (REM) sleep (p=0.009), an improvement in sleep efficiency (p=0.02), and less stage 1 sleep (p=0.04). Eight ALS patients had sleep-disordered breathing consisting of periods of hypoventilation, predominantly during REM sleep. Conclusions: Sleep-disordered breathing occurs in patients with ALS and is similar to patients without ALS with respiratory muscle weakness. No obstructive sleep apnea was observed. One potential reason for its absence might be the inability of patients with respiratory muscle weakness to generate an inspiratory pressure greater than the upper airway closing pressure. This hypothesis should be addressed in future studies.

US$19.90

PMID: 8797409

DOI: 10.1378/chest.110.3.664


Other references

Brodner, G.; Pogatzki, E.; Van Aken, H., 1998: A modern concept of postoperative pain therapy. Pain relief should be considered part of a multimodal postoperative approach. Combining patient-controlled pain therapy with other measures i.e. respiratory therapy or early mobilisation improves the outcome after surgery. In many patients adequat...

Parenteau N.L.; Eckert R.L.; Rice R.H., 1987: Primate involucrins antigenic relatedness and detection of multiple forms. Hominoid apes (gorilla, chimpanzee, orangutan, gibbon), Old World monkeys (rhesus, cynomolgus), New World monkeys (owl, cebus), and a prosimian (lemur) express involucrin-like proteins in cultured keratinocytes. Primate involucrins can be precipit...

Blum, M., J.; Mclachlan, J., S.; Saunders, C., J.; Herrick, J., D., 2005: Characterization of microsatellite loci in Schoenoplectus americanus (Cyperaceae). Schoenoplectus americanus is a model organism for studying ecological and ecosystem responses of salt marsh plant communities to global climate change. Here we characterize 16 microsatellite loci in S. americanus to facilitate studies on the genet...

Patnayak, R.; Prayaga, A.; Anuradha, S.; Ahmed, F.; Jena, A.; Gupta, V., 2007: Pigmented dermatofibrosarcoma protuberance (Bednar tumor). European Journal of Dermatology 18(1): 98-100

Anselmo G.; Felici E.; Merlo F.; Fandella A.; Bassi E.; Maccatrozzo L.; Checchin P., 1989: Prostatic cancer staging and results of radical prostatectomy. The authors present their experience about the accuracy of staging and the results of radical prostatectomy in prostatic cancer. From January 1978 to September 1988, 47 patients with clinically localized prostatic carcinoma underwent staging pelvi...

Cestari, V.; Castellano, C., 1997: MK-801 potentiates morphine-induced impairment of memory consolidation in mice: Involvement of dopaminergic mechanisms. The purpose of the present research was to study the interaction between the non-competitive NMDA receptor antagonist MK-801 and morphine in memory consolidation. The involvement of dopamine (DA) mechanisms in this interaction was also studied. Fo...

Pelletier, S.; Iyer, K.; Chang, C., 1970: Oxidative degradation of resin acids. Journal of organic chemistry: 35 (10) 3535-3538

Iwano, T.; Yamamoto, A.; Omori, K.; Kawasaki, K.; Kumazawa, T.; Tashiro, Y., 1990: Quantitative immunogold localization of Na+,K(+)-ATPase alpha-subunit in the tympanic wall of rat cochlear duct. Ultrastructural localization of Na+,K(+)-ATPase was quantitatively investigated in the tympanic wall of rat cochlear duct by use of the protein A-gold method, using an affinity-purified antibody against the alpha-subunit of rat kidney Na+,K(+)-ATP...

Rostock, R.A.; Kopher, K.A.; Bauer, T.W.; Klein, J.L., 1985: The effect of iron dextran on ferritin content and 131I-antiferritin localization in experimental hepatomas. Polyclonal 131I rabbit antirat ferritin localizes in certain hepatoma models. The effect of intraperitoneal iron dextran on tumor and sera ferritin content and tumor and normal tissue localization with 131I antiferritin was studied. Separate group...

Mouriquand, G.; Leulier, A.; Weill, M.L.; Morin, G., 1932: Reversibilite des modifications de la chronaxie dans le rachitisme experimental du rat. Chronaxie of young rats with rickets induced by feeding for 20-23 d. on Pappenheimer's diet 85 with or without CaCO3 (Ca/P = 8.9 and 3.6 respectively) was 2-8 times greater than before dieting. This increase was rapidly reversible and unrelat...