+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Sodium fluoride prevents bone loss in primary biliary cirrhosis

, : Sodium fluoride prevents bone loss in primary biliary cirrhosis. Journal of Hepatology 15(3): 345-349

Low-bone-turnover osteoporosis is a common complication of primary biliary cirrhosis (PBC). Since sodium fluoride stimulates bone formation we assessed the effect of this drug on bone mass in a 2-year, prospective, double-blind trial including 22 women with PBC who were randomly assigned to receive sodium fluoride (50 mg/day) or placebo. All received calcium supplements and low doses of vitamin D. Bone mineral density of the lumbar spine was measured by dual-photon absorptiometry initially and every 6 months. Vertebral fractures were evaluated in thoracic and lumbar spine initially, and after 1 and 2 years. Seven patients in the fluoride group and eight in the placebo group completed the trial. In the fluoride group, bone mineral density did not change after 2 years (initial 1.05 +- 0.07, final 1.07 +- 0.06 g/cm-2; p = n.s.). In the placebo group, however, bone mineral density decreased significantly (initial 1.00 +- 0.07, final 0.93 +- 0.06 g/cm-2; p = 0.03). Moreover, in the fluoride group bone mineral density increased by 2.9 +- 3.6%, and in the placebo group decreased by 6.6 +- 2.6% (p = 0.04). None of the patients developed new vertebral or non-vertebral fractures. Treatment with sodium fluoride did not impair liver function or cholestasis in PBC. These results indicate that sodium fluoride prevents bone loss in PBC and therefore might be considered as a possible therapeutic agent for osteoporosis associated with this liver disease. Since a small number of patients completed the trial, further studies are required.


PMID: 1447501

DOI: 10.1016/0168-8278(92)90066-X

Other references

Kuiumdzhiev, I.; Spasova, N., 1966: Forms of variability in Proteus vulgaris through the influence of lithium chloride or penicillin. Izvestiia Na Mikrobiologicheskiia Institut 18: 121-128

Greenblatt, D.J.; Legangneux, E.; Harmatz, J.S.; Weinling, E.; Freeman, J.; Rice, K.; Zammit, G.K., 2006: Dynamics and kinetics of a modified-release formulation of zolpidem: comparison with immediate-release standard zolpidem and placebo. Modified-release (MR) zolpidem was developed to maintain effective plasma concentrations during the 3- to 6-hour post-dosage interval, corresponding to the middle portion of the typical sleep interval. Modified-release zolpidem (12.5 mg), standard...

How J.; Scott R.M.; Thomson A.W.; Gerrie L.M.; Khir A.S.M.; Bewsher P.D.; Horne C.H.W., 1984: Pregnancy associated alpha 2 glycoprotein may modulate disease activity in autoimmune thyroid disease during pregnancy. Scottish Medical Journal 29(3): 202

Fairbanks G.; Patel V.P.; Carter D.P.; Dino J.E., 1982: Red cell membrane shape change role of vanadate sensitive magnesium atpase. Federation Proceedings 41(3): ABSTRACT 1422

Imrie, A.H.; Bowden, M.; Manderson, W.G., 1975: A comparison of diabetic diets as prescribed and as eaten. Health Bulletin 33(5): 203-209

Gorodkin, J.; Knudsen, B.; Zwieb, C.; Samuelsson, T., 2001: SRPDB (Signal Recognition Particle Database). Signal recognition particle (SRP) is a stable cytoplasmic ribonucleoprotein complex that serves to translocate secretory proteins across membranes during translation. The SRP Database (SRPDB) provides compilations of SRP components, ordered alphab...

Di Pietro, F.; Stanton, T.R.; Moseley, G.Lorimer.; Lotze, M.; McAuley, J.H., 2017: An exploration into the cortical reorganisation of the healthy hand in upper-limb complex regional pain syndrome. Recent evidence demonstrated that complex regional pain syndrome (CRPS) is associated with a larger than normal somatosensory (S1) representation of the healthy hand. The most intuitive mechanism for this apparent enlargement is increased, i.e. co...

Inacio, R.Cantarim.; Klautau, G.Burlamaqui.; Murça, M.Aparecida.S.; da Silva, C.Barreto.; Nigro, S.; Rivetti, L.Antonio.; Pereira, W.Lopes.; Salles, M.Jose.Costa., 2016: Microbial diagnosis of infection and colonization of cardiac implantable electronic devices by use of sonication. The clinical utility of sonication as an adjunctive diagnostic tool for the microbial diagnosis of cardiac implantable device-associated infections (CIDAIs) was investigated. The implants of 83 subjects were investigated, 15 with a CIDAI and 68 wi...

Buxton, B.M.; Fallert, R., 1974: Impact of dairy product imports on U.S. milk price. A static partial equilibrium model is developed to evaluate the short-run impact of dairy product imports on U.S. milk prices. Results showed that importing an additional 500 million pounds of milk equivalent in dairy products would reduce U.S. mi...

Førde, R., 1998: Who is to define the futility of treatment--the patient or the physician?. The definition of medical futility has two important components; the probability and the desirability of reaching a particular goal by medical intervention. Futility embodies a normative component. In this paper it is argued that physicians must r...