geoscience.net logo
+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Sodium nitroprusside metabolism in children during hypothermic cardiopulmonary bypass


, : Sodium nitroprusside metabolism in children during hypothermic cardiopulmonary bypass. Anesthesia and Analgesia 81(5): 952-956

Ten children, aged 1-7 yr, presenting for repair of complex congenital heart lesions, were prospectively studied. A ketamine, halothane/isoflurane, and fentanyl anesthetic was used. After initiation of hypothermic cardiopulmonary bypass, sodium nitroprusside (SNP) was titrated as necessary to maintain a target mean arterial blood pressure of 35-60 mm Hg. Blood samples drawn immediately prior to starting SNP infusion, every 15 min during infusion, and at 1, 4, and 24 h postinfusion were analyzed for whole blood cyanide (CN-) and serum thiocyanate (SCN-). Blood gas analysis was performed every 30 min during SNP infusion. A maximum CN- level > or = 1.0 micrograms/mL was observed in two children; four others had maximum CN- levels between 0.5 micrograms/mL and 1.0 micrograms/mL (normal, < 0.2 micrograms/mL). No child had a clinically important increase of SCN- subsequent to SNP infusion. There was substantial variability in observed CN- accumulation during SNP infusion. CN- levels during the first 60 min correlated with the average SNP rate of administration (P = 0.02). Cyanide levels rapidly decreased after termination of SNP infusion and were undetectable 4 h postinfusion. Despite the short-term increase of CN- level, no child showed biochemical signs of toxicity (acidosis or increased mixed venous oxygen tension).

US$19.90

PMID: 7486083

DOI: 10.1213/00000539-199511000-00010


Other references

Beem, A.Leo.; Geus, E.J.C.de.; Hottenga, J-Jan.; Sullivan, P.F.; Willemsen, G.; Slagboom, P.Eline.; Boomsma, D.I., 2005: Combined linkage and association analyses of the 124-bp allele of marker D2S2944 with anxiety, depression, neuroticism and major depression. A central issue in psychiatric genetics is whether positive findings replicate. Zubenko et al. (2002b, Mol. Psychiatry 7:460-467) reported an association of the 124-bp allele of D2S2944 with recurrent early-onset major depression for females. We t...

Schwarz, H.G., 1954: Fatty acids of medium chain length as therapeutic agents against dermatomycosis. Nine contributions to the literature on the use of fatty acids in the therapy of dermatomycoses are mentioned in this brief review of the subject.

Lobzanidze, E.D., 1958: First stages in the formation of annual rings.. Differentiation of xylem elements was studied in wood samples taken at intervals through the growing season from 74 woody species (7 conifers and 12 each of diffuse- and ring-porous hardwoods are named) growing in Caucasia. The results are reporte...

Hasselrot, T.E., 1938: Some lichens from Gotland. Several lichens are reported for the first time on Goltand. An incomplete list of lichens found is given with a geogr. distr. of each. The work of Degelius (1936) is supplemented and discussed.

Tutton, P.J., 1973: Control of epithelial cell proliferation in the small intestinal crypt. Cell and Tissue Kinetics 6(3): 211-216

Jarvi, S.I.; Farias, M.E.M.; Howe, K.; Jacquier, S.; Hollingsworth, R.; Pitt, W., 2013: Quantitative PCR estimates Angiostrongylus cantonensis (rat lungworm) infection levels in semi-slugs (Parmarion martensi). The life cycle of the nematode Angiostrongylus cantonensis involves rats as the definitive host and slugs and snails as intermediate hosts. Humans can become infected upon ingestion of intermediate or paratenic (passive carrier) hosts containing s...

Loobuyck, H., A.; Duncan, I., D., 1993: Destruction of CIN 1 and 2 with the Semm cold coagulator: 13 Years' experience with a see-and-treat policy. Objective: To assess the efficacy of the Semm Cold Coagulator (100 degree C) for CIN 1 and 2 applying a 'see and treat' policy. Design: Retrospective review of women with CIN 1 and 2 seen and treated at their first visit when specific cr...

Milov, D.E.; Hill, M.; Andres, J.M.; Cynamon, H.A.; Hendeles, L., 1989: Measurement of plasma prednisolone level to evaluate a prednisone treatment failure in an adolescent with Crohn's disease. A 14-year-old boy experienced multiple hospitalizations because of symptoms due to Crohn's disease involving the stomach, duodenum, and ileum. He maintained that oral corticosteroids were not effective for control of his symptoms. However, i....

Cheney Eric S., 1981: The hunt for giant uranium deposits. American Scientist 69(1): 37-48

Dong, B.; Li, D.; Li, R.; Chen, S.C-A.; Liu, W.; Liu, W.; Chen, L.; Chen, Y.; Zhang, X.; Tong, Z.; Xia, Y.; Xia, P.; Wang, Y.; Duan, Y., 2015: A chitin-like component on sclerotic cells of Fonsecaea pedrosoi inhibits Dectin-1-mediated murine Th17 development by masking β-glucans. Fonsecaea pedrosoi (F. pedrosoi), a major agent of chromoblastomycosis, has been shown to be recognized primarily by C-type lectin receptors (CLRs) in a murine model of chromoblastomycosis. Specifically, the β-glucan receptor, Dectin-1, mediates...