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Stability studies of furosemide/beta-cyclodextrin kneaded system


, : Stability studies of furosemide/beta-cyclodextrin kneaded system. Pharmaceutical & Pharmacological Letters 8(2): 65-68, April

In this study, with the purpose of enhancing the solubility, hence the dissolution rate and stability of Furosemide (FR), inclusion complexations was prepared with beta-cyclodextrin (beta-CD) by using kneading method. These complexes and pure active material as control purpose were kept at 25degreeC, 35degreeC and 55degreeC at a dry medium and at the same temperatures, at a medium with 80% relative humidity for 3 months. Quantification analyses, dissolution rate tests and differential scanning calorimetry (DSC) measurement were made on the samples taken at days 0, 15, 30, 60 and 90 from complexations and pure FR stored under different conditions. Pure FR was degraded as much, while FR/betaCD complex remained stabile even in the most extreme conditions. In conclusion, it has been found that beta-CD, which used as a complex-forming agent, substantially enhances the solubility, dissolution rate and stability of active material.

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