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Stress reinstates cocaine-seeking behavior after prolonged extinction and a drug-free period


, : Stress reinstates cocaine-seeking behavior after prolonged extinction and a drug-free period. Psychopharmacology 128(4): 408-412

We have shown previously, using an animal model of relapse, that acute exposure to intermittent footshock stress induces reinstatement of heroin-taking behavior in rats. Here we report that in rats trained to self-administer cocaine, exposure to acute intermittent footshock stress induces reinstatement of cocaine-taking behavior after prolonged extinction sessions and after a 4- to 6-week drug-free period; an effect comparable to that induced by a priming injection of cocaine. Animals were initially allowed to self-administer cocaine HCl (1.0 mg/kg per infusion, IV) during one 3-h session/day for 12 days. Subsequently, extinction conditions were introduced by substituting saline for cocaine so that lever-pressing resulted in IV infusions of saline rather than of drug. Extinction conditions were maintained until animals made 15 responses or less in the 3 h, after which animals were given saline infusions at the start of each daily session to establish baseline responding of ten responses or less. Subsequently, animals were tested for reinstatement of responding for saline infusions following a non-contingent injection of cocaine (2.0 mg/kg, IV) and exposure to intermittent footshock (10 min, 0.5 mA, 0.5 s on, mean off period of 40 sec). After an additional 4- to 6-week drug-free period, tests for reinstatement were repeated. Reinstatement of cocaine-taking behavior was observed in both sets of tests in response to footshock and cocaine. These results extend previous reports from this laboratory that footshock stress is an effective stimulus for reinstatement of drug-taking behavior in the rat.

US$19.90

PMID: 8986011

DOI: 10.1007/s002130050150


Other references

Montoro, O.; Sanche, D.B.Stamant, Y.Sirven, A., 1950: Address at the grave of Alberto Sanchez de Bustamante y Sirvén. Vida Nueva 66(4): 81-82

Graddon, W.D., 1957: Approach to Discomycetes. A general survey of collecting, examin-ing and naming discomycetes.

Voineskos, G., 1976: Locked wards in Canadian mental hospitals. Canadian Medical Association Journal 115(5): 386-389

Shiba, N., 2016: Identification of novel pathogenic gene mutations in pediatric acute myeloid leukemia by whole-exome resequencing. A new class of gene mutations, identified in the pathogenesis of adult acute myeloid leukemia (AML), includes DNMT3A, IDH1/2, TET2 and EZH2. However, these mutations are rare in pediatric AML cases, indicating that pathogeneses differ between adul...

Gerasimova, N.; Kiseleva, S.; Bekhtereva, M., 1973: Influence of temperature and aeration on lipid biosynthesis and composition in the minus forms of the heterothallic fungi Blakeslea trispora and Cunninghamella elegans. Microbiology Transl 1973, 42 (1) 24-28

West O.L.O.; Leckie R.M.rk; Leithold Elana; McCormic Michael E., 1997: Foraminiferal response to sea level change in Cenomanian-Turonian sections (Upper Cretaceous) of the Western Interior sea. Abstracts with Programs - Geological Society of America 29(6): 53

Dodd, J.G.iffin, E., 1989: Floristics of the Banksia woodlands. Journal of the Royal Society of Western Australia1(4): 89-90

Furukawa, T.; Ito, K.; Nuka, S.; Hashimoto, J.; Takei, H.; Takahara, M.; Ogino, T.; Young, M.F.; Shinomura, T., 2010: Absence of biglycan accelerates the degenerative process in mouse intervertebral disc. A study of the histologic changes of the intervertebral discs (IVDs) in biglycan (Bgn)-deficient mice. In this study, we investigate whether the absence of Bgn accelerates the degenerative process in mouse intervertebral disc (IVD). Proteoglycans...

Li, R.; Gao, M.; Dai, S.; Li, X., 2003: The identification of 5 new serotypes of Bacillus thuringiensis from soil in China. Five new strains of Bacillus thuringiensis(Bt) from soil in China were classified. 5 new H-serotypes: H42, H43, H56, H60 and H62 were identified. There were some distinction in the morphology, biochemical reaction and toxicity against species of i...

Zhang, Y.; de Pablo, J.J.; Graham, M.D., 2012: An immersed boundary method for Brownian dynamics simulation of polymers in complex geometries: application to DNA flowing through a nanoslit with embedded nanopits. This work presents an immersed boundary method that allows fast Brownian dynamics simulation of solutions of polymer chains and other Brownian objects in complex geometries with fluctuating hydrodynamics. The approach is based on the general geome...