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Strong allelic selection in the course of brother times sister matings in mice

, : Strong allelic selection in the course of brother times sister matings in mice. Journal of Heredity 84(1): 49-56

A set of 36 recombinant congenic mouse strains, resultings from crosses between B10.D2 and DBA/2, was created. During the backcross phase, animals were selected for their sensitivity to the graft-versus-host reaction induced by a B10.D2 hematopoietic cell transplant after irradiation. The progress of inbreeding was followed throughout the brother times sister phase by determining the allelic form of 14 genetic markers. During the backcross phase, the mean selective value per generation and per marker for the heterozygous allelic combination was 2.81 (1 for the homozygous B10.D2). During the brother times sister phase, this value was 1.15 and 0.30 for the heterozygous and the DBA/2 homozygous combinations, respectively (1 for the homozygous B10.D2). The origin of this strong allelic disadvantage for the DBA/2 homozygote, in the face of countervailing selection, is discussed. These data strongly suggest coadaptation between alleles constituting the genome of the inbred strains of the laboratory mouse, resulting in strong counterselection of the alleles derived from one inbred strain when a small amount is spread over the genetic background of another inbred strain.


Other references

Clayton J.L.; Lubeck C.M.; King J.D.; Daws T.A., 1987: Organic geochemistry and petroleum potential of Pennsylvanian black shales, Powder River and Denver basins. AAPG Bulletin 71(5): 539

Hoffbrand, B.I.; Kininmonth, D.A., 1967: Potentiation of anticoagulants. British Medical Journal 2(5555): 838-839

Hurst, J.W.llis; Healy, B.P.; Humphries, J.O.neal; Becker, A.E.; Alpert, J.S., 1994: Collagen vascular disease and the heart. Hurst, J W [Editor], Alpert, J S [Editor] Diagnostic atlas of the heart 545-551

Porzionato, A.; Macchi, V.; Stecco, C.; Vigato, E.; Tiengo, C.; Parenti, A.;, R., 2008: Morphometric analysis of the inferior olivary complex in infants and adults. In the literature, few studies detailed morphometric parameters of the inferior olivary complex, and mainly applying biased methods based on counting in a two-dimensional plane. In the present work, the unbiased quantitative method of the optic di...

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Excell, T.; Mellet, P., 1986: Refined sugar storage trials using various types of 25 kg paper bags. Proceedings of the annual congress South African Sugar Technologists' Association: 0th) 112-115

Bracegirdle, R.C., 1963: Post-glacial invasions of Man by the animal kingdom. Proceedings of the Isle of Man Natural History and Antiquarian Society, 6: 388-401

Schnee R.; Eichner K., 1987: Analytical determination of the roasting extent of cocoa. The chemical changes which occur in cocoa ingredients during roasting, leading to the typical Maillard reaction products, were investigated. Highly volatile compounds were analysed by head-space gas chromatography and the water vapour distillate a...

Swartz, R.D.; Messana, J.M.; Boyer, C.J.; Lunde, N.M.; Weitzel, W.F.; Hartman, T.L., 1994: Successful use of cuffed central venous hemodialysis catheters inserted percutaneously. Although endogenous fistulae and grafts are preferred for permanent hemodialysis access, central venous catheters are often required for varying intervals when creating permanent access is not feasible. The prospective experience with 118 catheter...

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