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Study on human recombinant gamma interferon anti-idiotypic antibody induced NK cell activity in vitro


, : Study on human recombinant gamma interferon anti-idiotypic antibody induced NK cell activity in vitro. Chinese Journal of Microbiology & Immunology (Beijing) 12(4): 259-261

Human recombinant gamma interferon (rhIFN-gamma) anti-idiotypic antibody was used to regulate NK cytotoxicity of BALB/c mice spleen cell. Our study demonstrated that with increasing doses of anti-Id, NK activity was increased. There is no significant difference between anti-Id and rhIFN-gamma (P gt 0.05), and both of them could be neutralized by rhIFN-gamma McAb. Our results show anti-Id has the internal image function of rIFN-gamma.

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