+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Survival and predictors of survival in patients with congestive heart failure due to Chagas' cardiomyopathy

, : Survival and predictors of survival in patients with congestive heart failure due to Chagas' cardiomyopathy. Circulation 90(6): 3098-3102

Background: The fundamental determinant of the natural history of Chagas' disease is cardiac involvement. Methods and Results: We studied 104 male patients with congestive heart failure due to Chagas' disease to estimate the survival distribution function and to evaluate age, functional class (FC), maximal oxygen consumption ( ovrhdot VO-2max), and ejection fraction (EF) as predictors of survival. Statistical evaluation was performed through univariate (Student's t test and chi-2 test) and multivariate analyses (Cox's regression model). Overall survival was 66% at 1 year, 56% at 3 years, and 48% at 5 years. Ages were not statistically different (P=.9811) between survivor (40.3+-8.7) and nonsurvivor (40.3+-9.4) groups. The ejection fraction(s) were statistically different (P=.0001) between survival (43.6+-9.9) and nonsurvival (30.6+-8.1) groups, as was ovrhdot VO-2max (P=.0001) (21.0+-4.7 and 15.0+-4.9, respectively). Most of the surviving patients were in FC II and most of the nonsurvivors were in FC IV (P=.0001). ovrhdot VO-2max (P=.0001) and EF (P=.0008) are highly associated with survival time in the multivariate analysis, but FC (P=.0578) is less important. Age (P=.9811) did not influence survival. Conclusions: We conclude that 50% of the patients with heart failure due to Chagas' disease die in 47 months and that ovrhdot VO-2max and EF are important indices of survival in this group.


PMID: 7994859

DOI: 10.1161/01.cir.90.6.3098

Other references

Yoganandan, N.; Pintar, F.A.; Gennarelli, T.A., 2007: High-speed 3-D kinematics from whole-body lateral impact sled tests. While lateral impact sled studies have been conducted to determine injuries, injury mechanisms, and derive human tolerance using post mortem human subject (PMHS) for the chest and pelvis regions of the human body, there is a paucity of three-dimen...

Leevy, C.B.; Cowan, J.; Patel, M., 1995: Immune complexes in AIDS with chronic viral hepatitis B and/or C. Hepatology 22(4 PART 2): 445A

Brunini, O.; Cardoso, M., 1998: Effect of soil water stress on stomatal resistance and leaf water potential of rubber tree seedlings. The effects of soil water stress on leaf water potential, stomatal resistance and recovery of leaf water potential after severe water stress was studied in Hevea seedlings using open-pollinated progenies of clones IAN 873, IAN 713 and RRIM 600 and...

Mattingly Shirley, 1988: Response and recovery planning with consideration of the scenario earthquakes developed by California Division of Mines and Geology. Open-File Report - U S

Ehni, G., 1950: "False" localizing signs in intracranial tumor; report of a patient with left trigeminal palsy due to right temporal meningioma. A.M.A. Archives of Neurology and Psychiatry 64(5): 692-698

Smilanick, J.; Mlikota, F.H.rtsell, P.; Muhareb, J.; Denis-Arrue, N., 2000: The quality of three table grape varieties fumigated with methyl bromide at doses recommended for the control of mealybugs. 'Ruby Seedless', 'Red Globe', and 'Prima Red' table grapes were fumigated with the treatment schedule of the USDA-Animal Plant Health Inspection Service recommended for the control of mealybugs. Methyl bromide was app...

Stridsberg S., 1984: Aptychopsid plates jaw elements or protective operculum. The 3 plates characteristic of Aptychopsis have been described as a jaw apparatus in this orthocone cephalopod as well as an operculum for it. Due to the limited material, interpretations have in various cases been made from photographic illustrat...

Abreu, G.R.; Vassallo, D.V.; Mill, J.G., 1987: The Na+-Ca2+ exchange mechanism as a regulator of post rest contractions in cardiac muscle. The effects of external Na+ concentration and stimulation rate changes on the post rest contractions of rat myocardium were studied. An increase in external Na+ concentration or in stimulation rate causes relative potentiation of the post rest con...

McArdle, Peadar, 2008: Economic impact of the geoscience sector in Ireland. The Republic of Ireland has a small, but flourishing, open economy, with a Gross National Product (GNP) of Euro 149.1 billion for a population of 4.17 million people in 2006. The geosciences have been a significant, but largely unrecognised, contr...

Bar-Eli, M., 2000: Role of AP-2 in tumor growth and metastasis of human melanoma. We previously demonstrated that expression of the cell surface adhesion molecule MCAM/MUC18 correlates directly with the metastatic potential of human melanoma cells. In addition, the progression of human melanoma towards the metastatic phenotype...