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Synthesis of methyl (5Z,8Z,11Z,14Z,17E)-eicosapentaenoate and methyl (4Z,7Z,10Z,13Z,16Z,19E)-docosahexaenoate

, : Synthesis of methyl (5Z,8Z,11Z,14Z,17E)-eicosapentaenoate and methyl (4Z,7Z,10Z,13Z,16Z,19E)-docosahexaenoate. Chemistry and Physics of Lipids 74(2): 185-193

(3Z,6Z,9Z,12E)-Pentadecatetraenal, a common intermediate in the synthesis of methyl DELTA-17t EPA and methyl DELTA-19t DHA, was obtained by copper(I)-catalyzed coupling between the Grignard reagent of 1,1-diethoxy-3-butyne and (Z,E)-1-bromo-5,8-undecadien-2-yne followed by semi-hydrogenation of the resulting diendyne.


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