geoscience.net logo
+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

TaqI polymorphic sites at the human dopamine beta-hydroxylase gene possible associated with biochemical alterations of the catecholamine pathway in schizophrenia


, : TaqI polymorphic sites at the human dopamine beta-hydroxylase gene possible associated with biochemical alterations of the catecholamine pathway in schizophrenia. Psychiatric Genetics 8(1): 19-24, Spring

Two parts of the dopamine beta-hydroxylase (DBH) gene, one a 7.5-kb single copy fragment (F1) spanning the 5'-flanking region to exon 3 and the second a 9.0-kb single copy fragment (F2) spanning exon 3 to exon 7, were amplified by a long PCR procedure in 161 unrelated patients with schizophrenia and 67 unrelated control subjects. The PCR products were completely digested with the restriction enzyme TaqI. These subjects were classified into genetic subgroups according to the TaqI restriction fragment length polymorphisms (RFLPs) for the human DBH gene, and the association of the TaqI RFLPs with biochemical alterations of the catecholamine pathway in schizophrenia was then examined. The frequencies of the two TaqI polymorphic sites did not show significant differences between the patients and control subjects, but the TaqI RFLPs were found to be associated with biochemical alterations of the catecholamine pathway in schizophrenia.

US$29.90

PMID: 9564683


Other references

Maher, J.M.; Cherrington, N.J.; Klaassen, C.D., 2003: Tissue and gender-specific expression of the multidrug resistance-associated proteins 1-6 in mice. Toxicological Sciences 72(S-1): 257, March

Satoh, K.; Kotake, S.; Nakamura, T.; Ishitani, R.; Ueno, H., 1978: Pulmonary lesions of guinea pigs, mice, and rats infected with Metastrongylus apri. In guinea-pigs infected orally with 100, 250, 500 or 1000 Metastrongylus apri larvae, petechiae and parasites were observed in the lung alveoli after 5 days. From the 7th to 30th days growing larvae were found on the way from the bronchioli to bro...

Anonymous, 1971: The Director-General's programme of work and budget for 1972-73. The total Programme of Work and Budget proposed for 1972-73 amounts to $87, 090, 000. This represents. an increase of $16, 522, 000 ($14, 522, 240 cost increases, and $1, 999, 760 programme increases) over the approved 1970-71 budget of $72, 568,...

Koster, S., 1955: Serious and dangerous organic and functional disorders helped by hypnosis. Geneeskundige Gids 33(24): 481-490

Burns, 1989: Thermoelectric power during magnetic-field-induced localization in degenerately doped n-type Ge. Physical Review. B, Condensed Matter 40(8): 5473-5478

Ardouin, P., 1964: Observations On A Case Of Hodgkin's Disease With A Pharyngeal Onset. Revue de Laryngologie - Otologie - Rhinologie 85: 687-696

Buzun, L.; Modzelewska, B.; Kostrzewska, A.; Kleszczewska, E.; Kleszczewski, T., 2017: The sources of calcium for noradrenaline-induced contraction in the human thoracic internal artery. The aim of the present study was to examine the contribution of intracellular and extracellular calcium sources in contraction caused by noradrenaline (NA) of the human internal thoracic artery (ITA) in vitro. Distal segments of ITA were obtained...

Weissbach L.; Bussar Maatz R., 1986: Modified retroperitoneal lymph node dissection as a means to preserve ejaculation in clinical stage i. Uicc (Union Internationale Contre Le Cancer, International Union Against Cancer) 14th International Cancer Congress, Budapest, Hungary, Aug 21-27, Abstracts, Lectures, Symposia And Free Communications, Vols 1, 2, 3, Late Abstracts, And Register Xvi+479p (Vol 1); Xvi+298p (Vol 2); Xvi+531p (Vol 3); 15p (Late Abstracts); 40p (Register) S Karger Ag: Basel, Switzerland; New York, N Y , Usa; Akademiai Kiado: Budapest, Hungary Paper 435

Dey, S.; Mahanti, B.; Khila, S.; Mazumder, B.; Gupta, S.Das., 2013: Formulation development and optimization of bilayer tablets of aceclofenac. The objective of the present study was to develop bilayer tablets of aceclofenac that are characterized by initial burst drug release followed by sustained release of drug. The fast-release layer of the bilayer tablet was formulated using microcry...

Thomas, M.; Basu, N.; Oke, T.; Yiu, C-Yiu., 2009: Appendiceal polypectomy at colonoscopy. Digestive Surgery 26(2): 121-122