geoscience.net logo
+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Technetium-99m HMPAO cerebral scintigraphy: A reliable, noninvasive method for determination of brain death


, : Technetium-99m HMPAO cerebral scintigraphy: A reliable, noninvasive method for determination of brain death. Clinical Nuclear Medicine 18(2): 104-109

To determine the usefulness of cerebral blood flow imaging for the diagnosis of brain death, 4 female and 12 male patients, aged 19 to 69 years and suffering from various intracranial lesions, were studied. In addition to neurologic examination, electroencephalographic recording, and cerebral angiography, tomographic brain scintigraphy was performed using a SPECT system with a LEAP collimator after the intravenous administration of 555 MBq Tc-99m HMPAO. The radioisotopic scanning procedure revealed no intracranial perfusion in 14 of the 16 patients. Only minimal cerebellar blood flow was seen in one patient. In another, residual right-sided supratentorial flow was initially present but absent in a follow-up HMPAO SPECT. Carotid angiography (four-vessel contrast media angiography) confirmed the above results without exception. Because HMPAO is taken up by normal brain tissue with no significant redistribution for several hours, the tracer is particularly helpful in cases of suspected brain death. The quality of the tracer must be established by chromatography. Interpretation of the SPECT images produces reliable and reproducible results. In conclusion, cerebral blood flow imaging with HMPAO is a safe, noninvasive procedure for the determination of brain death, that produces fast, reliable, reproducible, and easy-to-interpret results.

US$29.90


Other references

Wiltbank, M.C., 1998: Information on regulation of reproductive cyclicity in cattle. This paper presents an overview of the role of hormones in the regulation of the oestrous cycle in cattle. Aspects covered include follicular development during the oestrous cycle and the physiological regulation of seasonal and postpartum anoestr...

Pitkanen, E.; Perheentupa, J., 1962: A biochemical investigation on 2 cases of fructose intolerance. Annales Paediatriae Fenniae 8: 236-244

Isola, M.; Furlanetto, S., 1968: Painful schisis. Minerva Ortopedica 19(12): 797-800

James, L.S.; Apgar, V.A.; Burnard, E.D.; Moya, F., 1963: Intragastric oxygen and resuscitation of the newborn. Acta Paediatrica 52: 245-251

Shang, X-D.; Qiu, X-L.; Tong, P.; Xia, K-Q., 2003: Measured local heat transport in turbulent Rayleigh-Bénard convection. Local convective heat flux in turbulent thermal convection is obtained from simultaneous velocity and temperature measurements in an aspect-ratio-one convection cell filled with water. It is found that fluctuations of the vertical heat flux are hi...

Gowher, H.; Zhang, X.; Cheng, X.; Jeltsch, A., 2005: Avidin plate assay system for enzymatic characterization of a histone lysine methyltransferase. Modification of proteins by protein methyltransferases has several important biological functions. Here, we study the methylation of histone H3 tail at position Lys9 by the Dim-5 historic lysine methyltransferase, which is involved in epigenetic s...

Karagezyan T.A., 1980: Occupational diseases of the teeth and oval cavity in aluminum workers. Gigiena Truda i Professional'nye Zabolevaniya (8): 42-43

Amitzur, G.; Shenkar, N.; Mueller, M.; Kraft, P.; Novikov, I.; Eldar, M.; Leor, J.; Raichlin, E.; Schoels, W., 2003: Refractoriness and conduction interaction during modulation of non-ischemic ventricular fibrillation by flecainide. Purpose: To study refractoriness and conduction interaction during modulation of non-ischemic ventricular fibrillation (VF) by flecainide. Methods: Isolated feline and rabbit hearts were used. (a) In the feline hearts (n=8), electrophysiological p...

Armit, H.W., 1907: The Toxicology of Nickel Carbonyl. Journal of Hygiene 7(4): 525-551

Kaneko, S.; Yamasita, N.; Hoshi, K., 1994: Human adjuvant disease. Ryoikibetsu Shokogun Shirizu: 1001-1003