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The detection of HIV-2 infection in southern India

, : The detection of HIV-2 infection in southern India. Indian Journal of Medical Research 97: 49-52

While HIV-1 is the principal etiologic agent of AIDS throughout the world, the genetically distinct HIV-2 has been recently credited with causing AIDS especially in the countries of West Africa. HIV-2 infection was first reported in India in the city of Bombay in 1991. This paper reports findings from an HIV-2 seroprevalence study of blood sera in southern India. Sera sampled were selected from among those collected from January 1988 to October 1990 from high-risk subjects and tested for antibody to HIV-1. Sera were screened for HIV-2 with ELISA and repeatedly reactive sera were confirmed with Western blot for HIV-2 and line immunoassay. 1 serum (0.16%) of the 604 sera initially tested was positive for HIV-2. Another serum was found positive in the 2nd set of 24 sera (4%). The 2 infected subjects were residents of Madras or Visakhapatnam. Although residents of the Vellore region respectively comprise 88% and 75% of the 2 sets of subjects, none was found to be positive for HIV-2. Since these findings confirm the existence of HIV-2 in India, the authors stress the need to monitor its spread in order to determine when blood from donors should start being screened for both HIV-1 and HIV-2.


PMID: 8505073

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