geoscience.net logo
+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

The effect of colestipol and cholestyramine on the systemic clearance of intravenous ibuprofen in rabbits


, : The effect of colestipol and cholestyramine on the systemic clearance of intravenous ibuprofen in rabbits. Journal of Pharmacy and Pharmacology 46(1): 73-75

The effect of oral administration of the non-absorbable anion-exchange resins cholestyramine and colestipol on the systemic clearance and other pharmacokinetic parameters of intravenously administered ibuprofen (25 mg kg-1) was studied in rabbits. Single doses of colestipol hydrochloride (0.4 g kg-1) or cholestyramine (0.17 g kg-1) were given 30 min before ibuprofen administration. In cholestyramine-treated rabbits a significant reduction in ibuprofen plasma concentration was observed compared with both control (water only) and colestipol-treated rabbits. Cholestyramine treatment resulted in a significant decrease in the terminal elimination half-life and the mean residence time. Furthermore, a 31% increase in the systemic clearance and 23% decrease in the area under the plasma concentration-time curve were also observed in cholestyramine-treated rabbits. Colestipol treatment did not change these parameters. The volume of distribution parameters (Vd-ss and Vd-area) did not change following either treatment. The changes in the pharmacokinetic parameters are compatible with an acceleration of ibuprofen elimination induced by oral administration of cholestyramine and not by colestipol. This effect is thought to be due to augmentation of net biliary excretion through enteric binding.

US$29.90

PMID: 8201531


Other references

Anonymous, 1982: Commission vice-president addresses council. A speech by C. Tugendhat to the Council of the National Farmers Union of Scotland is summarized together with the main questions and answers which followed. The speech stressed the need to balance economic, social and political factors in an agric...

Ardill J.; Hayes J.R., 1978: Somatostatin release in vitro. Scandinavian Journal of Gastroenterology Supplement 13(49):

Kask, K.; Jalakas, M., 2004: Winter damages of sweet cherry trees at the Rohu Experimental Station 1998-2003. A study was conducted in Estonia, involving sweet cherry cultivars (in quotation marks) and selections: 'Donissen's Gelbe Knorpelkirsche' (German origin), 'Leningradskaya Chernaya' (Russian origin), 'Gronkavaya'...

Benson, M.; Langston, M.A.; Adner, M.; Andersson, B.; Torinssson-Naluai, A.; Cardell, L.Olaf., 2006: A network-based analysis of the late-phase reaction of the skin. Background: The late-phase reaction (LPR) of the skin is an in vivo model of allergic inflammation.Objective: We sought to identify disease-associated pathways in the LPR using a network-based analysis.Methods: The LPR was examined by means of DNA...

Bespalov, V.G.; Aleksandrov, V.A.; Petrov, A.S., 2007: Anticarcinogenic action of dietary supplement pheocarpin and its active component. Anticarcinogenic action of dietary supplement Pheocarpin and its active component Natural Coniferous Complex (NCC), in particular, has been studied. Pheocarpin and NCC efficiently inhibited tumorigenesis in the mammary gland, large bowel, skin, ce...

Yamada, M.; Asandhi, A.A.; Purwati, E.; Dianawati, M., 2004: Control of cabbage clubroot disease by employing one-year crop rotation with three vegetable combinations in the West Java highlands of Indonesia. An experiment was conducted in Indonesia, during 2000-02 to determine the effects of one-year crop rotation on cabbage clubroot disease [Plasmodiophora brassicae]. The treatments comprised: mono-continuous cropping of cabbage cv. Green Coronet (V1...

Sinha, S.; Puri, S., 2003: Synthesis and anthelmintic activity of N- acetyl morpholine/pyrrolidine/ 1-methyl piperazine. Medicinal Chemistry Research 12(6-7): 377-378

Bray, T.S.; Kaczynski, A.; Albuquerque, K.; Cozzi, F.; Roeske, J.C., 2014: Role of image guided radiation therapy in obese patients with gynecologic malignancies. We investigated the effect of body mass index on setup errors by analyzing daily shifts required in treating patients undergoing image guided radiation therapy (IGRT) for gynecologic malignancies. <section-title>Methods and Materials</sec...

Borgsteede F.H.; Duyn S.P.J., 1988: Lack of reversion of a benzimidazole resistant strain of haemonchus contortus after six years of levamisole usage. The resistance level of Haemonchus contortus was studied on a farm where benzimidazole resistance had been detected in 1980 and where, since 1982, only levamisole had been used for worm control. Egg development tests gave LD50 values of 0.18, 0.19...

Anonymous, 2014: Correction. Evidence-Based Mental Health 18(1): 26-26