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The effect of treatment regimens for vaginitis and cervicitis on vaginal colonization by lactobacilli

, : The effect of treatment regimens for vaginitis and cervicitis on vaginal colonization by lactobacilli. Sexually Transmitted Diseases 22(5): 269-273

Background and Objectives: The goal of this study was to determine the effect of various treatment regimens on vaginal colonization by H-2O-2-positive and H-2O-2-negative lactobacilli. Study Design: The subset of women enrolled in a large longitudinal cohort study who had Chlamydia trachomatis (n = 13), bacterial vaginosis (n = 105), yeast vaginitis (n = 15), or mucopurulent cervicitis (n = 47) were compared with 93 women without genital infection from the same population. The effect of various treatment regimens on lactobacilli was evaluated. Results: Use of doxycycline, azithromycin, clotrimazole, and fluconazole had little effect on vaginal colonization by Lactobacillus. Use of oral or vaginal metronidazole led to an increase in Lactobacillus, which persisted 1 month after therapy. Intravaginal clindamycin use caused a decrease 1 week post-therapy, but at 1 month, levels of lactobacilli were similar to those in the metronidazole treatment group. Women treated with oral ampicillin had a modest increase in Lactobacillus levels. Conclusions: Use of antimicrobial agents for treating vaginitis and cervicitis do not cause a decrease in vaginal colonization by Lactobacillus, which is detectable 1 week to 1 month after treatment.


PMID: 7502179

DOI: 10.1097/00007435-199509000-00001

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