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The experimental study of myocardial lesion induced by both selenium and methionine deficiency in rats


, : The experimental study of myocardial lesion induced by both selenium and methionine deficiency in rats. Acta Nutrimenta Sinica 14(1): 58-62

According to the level of selenium (Se) and methionine (Met) in diet, Wistar rats were randomly divided into 3 groups: group A (normal Se and normal Met); group B (Low Se and normal Met); group C (low Se and low Met). The animals were sacrificed after 8-week feeding. The results showed that the alteration of myocardial ultrastructure was slight in group B. Decreased activities of cytochrome oxidase and succinate dehydrogenase of myocardial mitochondria and decreased activities of GSH-Px in the blood, heart and liver in group B were observed, as compared with those in group A. But the level of TBA was higher than that of group A. The above-mentioned changes in group C were extremely more apparent than group A or B, indicating both Se and Met deficiency in diet may concern the etiology of Keshan disease.

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