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The extracellular amino-terminal region of the parathyroid hormone (PTH)/PTH-related peptide receptor determines the binding affinity for carboxyl-terminal fragments of PTH-(1-34)

, : The extracellular amino-terminal region of the parathyroid hormone (PTH)/PTH-related peptide receptor determines the binding affinity for carboxyl-terminal fragments of PTH-(1-34). Endocrinology 134(2): 879-884

The recombinant human PTH/PTH-related peptide (PTHrP) receptor, when transiently expressed in COS-7 cells, binds (Nle-8,18,Tyr-34) bovine PTH-(7-34) amide (PTH-(7-34)), human PTH-(10-34)amide (PTH-(10-34)), and bovine PTH-(15-34)amide (PTH-(15-34)) with at least 50-fold higher affinity than does the rat receptor homolog. In contrast, PTH-(1-34) binding affinities are similar for both receptor homologs.


PMID: 8299582

DOI: 10.1210/endo.134.2.8299582

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