geoscience.net logo
+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

The melanocortin 1, 3, 4 or 5 receptors do not have a binding epitope for ACTH beyond the sequence of alpha-MSH


, : The melanocortin 1, 3, 4 or 5 receptors do not have a binding epitope for ACTH beyond the sequence of alpha-MSH. Journal of Endocrinology 155(1): 73-78

ACTH(1-39), and several shorter N- and/or C-terminally truncated fragments of ACTH, with and without N-terminal acetylation and/or C-terminal amidation, were tested for binding on a single eukaryotic cell line transiently and independently expressing the melanocortin MC1, MC3, MC4 and MC5 receptors. The results show that none of these MC receptors has specific binding epitopes for the ACTH peptides beyond the amino acid sequence of alpha-MSH, when tested for their ability to compete with 125I-labelled [Nle4,D-Phe7]alpha-MSH and ACTH. The MC3 receptor favours the natural desacetylated N-terminal end of the ACTH peptides, and it has generally more than 10-fold higher affinity for the ACTH peptides than the MC4 receptor. Considering earlier anatomical localisation data, together with the present data, we suggest that the MC3 receptor is the most likely candidate of the MC receptors to mediate the short-loop negative feedback release of corticotrophin-releasing factor (CRF) caused by ACTH/MSH peptides.

US$29.90

PMID: 9390008


Other references

Wearn, A.; Bhoopatkar, H., 2006: Evaluation of consent for peer physical examination: students reflect on their clinical skills learning experience. Early clinical skills teaching often requires students to learn through examining one another. This model should acknowledge ethical, practical and individual issues, disclosure and identification of abnormalities. Consent to peer physical examina...

Ardoin, P., 1961: Contribution a l'etude des Tenebrionidae malgaches. Le genre Anarmostodera Fair-maire. Natche, Tananarive: 89-96

Veverkova, L.; Kalac, J.; Capov, I.; Wechsler, J.; Pac, L.; Svizenska, I.; Pitr, V., 2006: Laser-tissue interaction in endovenous laser treatment. The authors present the results of recorded changes in the endothelium in rabbit's veins following photocoagulation by laser diode. This study concentrates mainly on the detailed description of individual changes in the rabbit's venous s...

Kinzig M.; Pilz D.; Naber K.G.; Sorgel F.; Schugg C.; Dehmlow C., 1992: Unique body fluid penetration of sparfloxacin spa in man. Program & Abstracts of the Interscience Conference on Antimicrobial Agents & Chemotherapy 32: 182

Yonenaga Yassuda Y.; D.S.uza M.J.; Kasahara S.; L'abbate M.; Chu H.T., 1985: Supernumerary system in proechimys iheringi iheringi rodentia echimyidae from the state of sao paulo brazil. In a sample of 13 animals (8 males and 5 females) of the spiny rat Proechimys iheringi iheringi from three localities of the State of Sao Paulo (Casa Grande, Ubatuba and Iguape) the diploid numbers were 2n = 61, 62, 63, 64 and 65 chromosomes due t...

Matthess G.; Isenbeck M., 1987: Pesticide behaviour in Quaternary sediments. Pesticides are very often spread in agricultural and forest areas covering important groundwater bodies in Quaternary sand and gravel deposits. They are mostly synthetic organic chemicals used for plant protection against predators and competing h...

Ruge, H.; Wolfensteller, U., 2010: Rapid formation of pragmatic rule representations in the human brain during instruction-based learning. The present functional magnetic resonance imaging study investigated the instruction-based learning of novel arbitrary stimulus-response mappings in order to understand the brain mechanisms that enable successful behavioral rule implementation in...

Huang, C.; Siu, M.; Vu, L.; Wong, S.; Shin, J., 2014: Factors influencing doctors' selection of dabigatran in non-valvular atrial fibrillation. This study was designed to examine the factors that influence doctors decision in initiating or switching from warfarin to dabigratran.MethodA survey questionnaire was sent to 181 doctors who were most likely to prescribe dabigatran (e.g. cardiolo...

Shimoji, K.; Fujioka, H.; Onodera, M.; Hokari, T.; Fukuda, S.; Fujiwara, N.; Hatori, T., 1991: Observation of spinal canal and cisternae with the newly developed small-diameter, flexible fiberscopes. Small-diameter (0.5-, 0.9-, and 1.4-mm) flexible fiberscopes were developed for visual diagnosis of spinal canal diseases. The fiberscopes were introduced via a Tuohy needle into the subarachnoid and epidural spaces of ten patients with various pa...

Mayers, D.L.; Chung, J.; Kohlbrenner, V.M.; Hall, D.B.; DeMasi, R.A.; Neubacher, D.; Buss, N.E.; Salgo, M.P., 2006: Seeking ethical designs for HIV clinical trials in treatment-experienced patients: an industry perspective. The long-term immunological efficacy of regimens including lopinavir/ritonavir (LPV/r) has not been assessed in HIV-infected HAART-experienced subjects. The present study included 452 consecutive HIV-infected outpatients starting LPV/r before May...