geoscience.net logo
+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

The prognostic significance of microvessel density and thymidine phosphorylase expression in squamous cell carcinoma of the esophagus


, : The prognostic significance of microvessel density and thymidine phosphorylase expression in squamous cell carcinoma of the esophagus. Cancer 82(7): 1225-1232, April 1

BACKGROUND. Squamous cell carcinoma (SCC) of the esophagus is among the most malignant of neoplasms and is associated with a dismal prognosis. Although tumor microvessel density (MVD) is an important prognostic factor in several carcinomas, its role in SCC of the esophagus is still controversial. Also, the role of thymidine phosphorylase (dThdPase), a key angiogenic growth factor, is yet to be delineated in this disease. METHODS. Immunohistochemical staining using monoclonal antibodies was used to quantify microvessel and dThdPase expression in archival tissue specimens from 93 patients with SCC of the esophagus. RESULTS. High dThdPase expression and high MVD were associated with tumor progression (size and stage) and lymph node metastasis, but only MVD was a predictor of survival. dThdPase expression was significantly correlated with depth of tumor invasion (P = 0.015). In multivariate analysis, MVD was an independent predictor of survival in the lymph node negative cases. A significant correlation was noted between MVD and dThdPase expression, with a correlation coefficient of 0.083 (P = 0.002). CONCLUSIONS. MVD is an independent factor in determining the prognoses of lymph node negative patients with SCC of the esophagus. dThdPase could be a key factor in the angiogenesis of this disease and may be responsible for its aggressive behavior.

US$19.90

PMID: 9529012

DOI: 10.1002/(sici)1097-0142(19980401)82:7<1225::aid-cncr3>3.0.co;2-e


Other references

Brosh, D.; Herz, I.; Laniado, S.; Miller, H.I.; Rosenschein, U., 1999: Percutaneous transluminal ultrasound thrombolysis in native coronaries in the setting of acute coronary syndromes. European Heart Journal 20(ABSTR SUPPL ): 506, Aug

Chan Y K.; Marshall P.R., 1987: Strain dependent inhibition of nitrous oxide reduction in denitrifiers by yeast extract. Pseudomonas sp. type strain H8 (ATCC 35402) was shown to be capable of denitrification but unable to reduce N2O in a complex medium containing 0.15% yeast extract. When added to a defined medium, autoclaved or filter-sterilized yeast extract from...

Odom, O.W.; Picking, W.D.; Hardesty, B., 1990: Movement of the tRNA but not the nascent peptide during peptide bond formation on ribosomes. Biochemistry (American Chemical Society) 29: 734-44

Werner I.; Berfenstam R., 1974: The nutrient consumption and food choice of elderly people in sweden part 1. Annales Academiae Regiae Scientiarum Upsaliensis (18): 61-75

Douglas, S.D.; Blume, R.S.; Wolff, S.M., 1969: Fine structural studies of leukocytes from patients and heterozygotes with the Chediak-Higashi syndrome. Blood 33(4): 527-540

Hatwalne, B.V.; Deshpande, D.R.; Ingle, V.N., 1970: Serum tocopherol levels in normal children. Indian Journal of Pediatrics 37(273): 509-510

Allanore, Y.; Batteux, F.; Avouac, J.; Assous, N.; Weill, B.; Kahan, A., 2007: Levels of circulating endothelial progenitor cells in systemic sclerosis. Contradictory results have been reported regarding vasculogenesis in systemic sclerosis (SSc). Our aim was to investigate bone marrow-derived circulating endothelial precursors (EPCs) and activated circulating endothelial cells (CECs) in SSc patie...

Caldwell, R.M.; Kraybill, H.R.; Sullivan, J.T.; Compton, L.E., 1934: Effect of leaf rust (Puccinia triticina) on yield, physical characters, and composition of winter Wheats. This is a full report of the results obtained by the authors in their study of the effect of leaf rust (Puccinia triticina) on the yield, physical characters, and composition of winter wheats at La Fayette, Indiana, in 1931. This season was very f...

Sharif, S.; Arreaza, G.A.; Delovitch, T.L., 2000: In vivo activation of NKT cells by alpha galactosylceramide prevents autoimmune type I diabetes. Diabetes Research & Clinical Practice 50(Suppl 1): S165, September

Baart, E.A.D.; Naber, H., 1973: Chemical weed control in maize. Interprovincial trials 1971/1972, series 660. Primatol A (atrazine) at 2-3 kg/ha applied at sowing gave good weed control without damaging the crop, particularly on the wetter soils. Primatol A + 2 l Citowett/ha applied after emergence gave good weed control provided that the weeds were not t...