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The regulation of insulin-like growth factor binding protein (IGFBP)-1 during prolonged fasting


, : The regulation of insulin-like growth factor binding protein (IGFBP)-1 during prolonged fasting. Clinical Endocrinology 39(3): 357-362

Objective: Insulin-like growth factor binding protein (IGFBP)-1 levels increase overnight, being inversely related to changes in insulin. With prolonged fasting IGFBP-1 levels increase further. In animal studies high IGFBP-1 levels increase plasma glucose levels possibly by regulating the insulin-like actions of 'bio-available' plasma IGF. Following prolonged fasting, there is an increase in insulin requirement. A proportion of this reversible insulin resistance may be due to inhibitory effects of high IGFBP-1 levels on IGF action. This study examined the regulation of IGFBP-1 in the presence of reversible insulin resistance. Subjects: Nine normal adult volunteers, seven female and two male (mean age 27.6 +- SD 2.6 years, range 21.7-46.0 years of normal body mass index were studied. Methods: Subjects fasted from 2200 h day 0 toi 0900 h day 3 (59 hours), the fast being completed with a 75-g glucose meal. At least one week later, an 11-hour overnight fast was performed, followed by a repeat glucose meal. Blood samples were taken at regular intervals from 0900 h day 1 and for 5 hours during both glucose meal studies via an indwelling cannula. Measurements: Serum levels of IGFBP-1, insulin, GH, glucose, IGF-I and cortisol were measured at varying intervals during the fast and both glucose meal studies. Results: Following the initial 11-hour overnight fast IGFBP-1 levels rose from (mean +- SEM) 32+-5 mu-g/l to reach a maximum of 144 +- 24 mu-g/l after 32 hours of fasting. IGFBP-1 levels then fluctuated, falling in the morning (3 +- 8 mu-g/l) and then rising overnight (126 +- 9 mu-g/l), but not regaining the initial peak levels. The increase of IGFBP-1 from overnight fasting levels was associated with a fall in plasma insulin from 5.7 +- 0.7 to 2.2 +- 0.2 mU/l. In comparison, 30 minutes after termination of the fast with the glucose meal, IGFBP-1 levels fell from 120 +- 11 to 24 +- 2 mu-g/l within 4 hours. After an overnight fast IGFBP-1 levels fell from 35 +- 5 to 13 +- 2 mu-g/l within 3 hours. There was glucose intolerance and increased insulin levels following the glucose meal preceded by the 59-hour fast when compared with the overnight fast. The fall of IGFBP-1 levels after the glucose meal was best expressed, taking into account subject variation, by the following regression equations: Glucose meal preceded by 11-hour last: log (IGFBP-1)=1.64-0.255 log (1 h previous insulin)(2 0.51); Glucose meal preceded by 59-hour fast: log (IGFBP-1) = 1.41-0.265 (1 h previous insulin) + 0.557 log (current glucose)(R-2 0.82). Conclusion: In man, insulin appears to regulate circulating IGFBP-1 levels in all circumstances, this regulation being unaffected by the resistance to insulin action induced by prolonged fasting. The high IGFBP-1 levels were statistically related to the higher glucose levels and may have directly contributed to the increased insulin requirement observed after prolonged fasting.

US$19.90

PMID: 7693379

DOI: 10.1111/j.1365-2265.1993.tb02377.x


Other references

Resnick, M.A.; Holliday, R., 1971: Genetic repair and the synthesis of nitrate reductase in ustilago maydis after uv irradiation. Molecular and General Genetics 111(2): 171-184

Mey, Eberhard., 1997: New cultural and natural history findings on the history of the Northern Bald Ibis Geronticus eremita Neuere kultur- und naturgeschichtliche Zeugnisse vom Waldrapp Geronticus eremita. Rudolstaedter Naturhistorische Schriften. November; 8: 3-17

Fiorito, P.; Burgos, J.M.; Miyakawa, M.F.rnandez; Rivas, M.; Chillemi, G.; Berkowski, D.; Zotta, E.; Silberstein, C.; Ibarra, C., 2000: Effect of Shiga toxin 2 on water and ion transport in human colon in vitro. Shiga toxin-producing Escherichia coli (STEC) colonize the lower segments of the human gastrointestinal tract, causing gastrointestinal and systemic diseases. In this study, the effects of Shiga toxin 2 (Stx2) on fluid absorption and ion transport...

Ng, J.; Barbhaiya, C.; Reichlin, T.; Nagashima, K.; John, R., 2014: Never Out of the Woods: Onset of Events in Long QT Syndrome Late in Life Provoked by Atrial Arrhythmias. The assessment of risk in the asymptomatic patient with long QT syndrome can often be a challenging task, particularly when the available evidence is limited to relatively small retrospective registries, not to mention the need to consider the eff...

Turner-Stokes, L., 2002: Standardized outcome assessment in brain injury rehabilitation for younger adults. To explore possible candidates for a common outcome measure for brain injury rehabilitation in younger adults. Patients recovering from brain injury pass through several different stages of rehabilitation, illustrated by the 'Slinky model&apo...

Soonawalla R., 1973: Vaginal techniques of surgical sterilization. INT PLANNED PARENTHOOD FED CLINICAL PROCEEDINGS OF FIRST INTERNATIONAL PLANNED PARENTHOOD FEDERATION SOUTH-EAST ASIA and OCEANIA REGIONAL MEDICAL and SCIENTIFIC CONGRESS SYDNEY, AUSTRALIA, AUG 14-18, 1972 250P ILLUS AUSTRALIAN and NEW ZEALAND JOURNAL OF OBSTETRICS and GYNAECOLOGY: MELBOURNE, AUSTRALIA 173

Sanina, V.A.; Golovenchits, E.I.; Zalesskii, V.G., 2012: Spin-wave excitations in superlattices self-assembled in multiferroic single crystals. Spin-wave excitations revealed in the dynamically equilibrated one-dimensional superlattices formed due to phase separation and charge carrier self-organization in doped single crystals of Eu(0.8)Ce(0.2)Mn(2)O(5) and Tb(0.95)Bi(0.05)MnO(3) multife...

Gedek, W., 1988: Results of monitoring trials on residues in foods of animal origin in Bavaria. Monitoring harmful substances in meat, finding sources of contamination, establishing trends and transmitting data to federal authorities are part of a self-regulatory scheme carried out by a panel of scientists on behalf of the Bavarian State Min...

Wisniewski, K.; Jachimowicz, A.; Holy, Z., 1995: Does endogenous nitric oxide participate in the action of vasopressin on memory?. Polish Journal of Pharmacology 47(SUPPL ): 124

Bicknell, D.J., 1974: Communication with the deaf mentally handicapped in hospital. Proceedings of the Royal Society of Medicine 67(10): 1029-1031