+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

The role of nitric oxide in cell injury

, : The role of nitric oxide in cell injury. Toxicology Letters (Shannon) 82-83(SPEC ISSUE): 233-237

Nitric oxide (NO) is a pathophysiological mediator with unique signal transducing properties. Signaling mechanisms are categorized as cGMP-dependent or cGMP-independent. Multiple interactions of NO with oxygen, superoxide, and transition metals determine the biological activity. Cyclic GMP-independent responses of NO account for the antimicrobial, the cytostatic, and the cytotoxic capacity of NO. Cytotoxicity is not only directed to harmful cells but also affects the NO-producing cell in a self-destructing loop. For macrophages and pancreatic beta-cells (RINm5F), we established NO-mediated apoptotic cell death. Endogenously generated or exogenously applied NO causes DNA cleavage after endonuclease activation. NO-mediated accumulation of the tumor suppressor p53 precedes apoptotic cell death.


PMID: 8597059

DOI: 10.1016/0378-4274(95)03481-1

Other references

Schatz, M.; Cook, F.; Nakahiro, R.; Petitti, D., 2003: Inhaled corticosteroids and allergy specialty care reduce emergency hospital utilization for asthma in an HMO population. Journal of Allergy & Clinical Immunology 111(2 Abstract Supplement): S276, February

Gayer-Anderson, C., 2016: The application of virtual reality technology to understanding psychosis : Commentary on Valmaggia et al. (2016): using virtual reality to investigate psychological processes and mechanisms associated with the onset and maintenance of psychosis: a systematic review. Social Psychiatry and Psychiatric Epidemiology 51(7): 937-939

Abercrombie, P.D.; Learman, L.A., 2015: Providing holistic care for women with chronic pelvic pain. Chronic pelvic pain (CPP) is one of the most common pain conditions affecting women and can have a significant impact on quality of life. Assessment of women with CPP is best approached in a comprehensive, systematic manner that includes explorati...

Tüzmen, S.; Basak, A.N.; Baysal, E., 1997: Rare beta-thalassemia mutation IVS-II-848 (C-A) first reported in a Turkish Cypriot family. American Journal of Hematology 54(4): 338-339

Lim, K.Ja.; Moon, J.Hee.; Yoon, D.Young.; Cha, J.Hyeon.; Lee, I.Jae.; Min, S.Jeong., 2008: Angiomyofibroblastoma arising from the posterior perivesical space: a case report with MR findings. Angiomyofibroblastoma is a rare benign soft tissue neoplasm that predominantly occurs in the genital region of middle-aged women. We present a case of an angiomyofibroblastoma that involved the posterior perivesical space in a 48-year-old woman. W...

Santos Acosta, V.H.; Carvajal Martinez, F., 1978: Morbidity-mortality of permanent teeth in juvenile diabetes mellitus. Revista Cubana de Estomatologia 15(1): 9-12

Vivard, I.; Tréchot, P.; Schmutz, J.L.; Cuny, J.F.; Weber, M.; Beurey, J., 1989: Phenytoin and hirsutism. Annales de Dermatologie et de Venereologie 116(8): 562-562

Anonymous, 2005: Statin Therapy: Clinical Trials, Guidelines, and New Directions. Proceedings from the 3rd Atorvastatin Global Investigators Meeting in Toronto, Ontario, Canada, June 2004. American Journal of Medicine 118 Suppl 12a: 1-67

Brunet, J., 1967: The unity of clinical instruction. L'union Medicale du Canada 96(3): 308-309

Machida Y., 1981: Study of specific dynamic action on some fresh water fishes. O2 uptakes attributable to specific dynamic action (SDA) were measured for 2 spp. of Eleotridae [Odontobutis obscura and Eleotris oxycephala], Centrarchidae (Lepomis macrochirus and Micropterus salmoides] and Cyprinidae [Rhodeus rhombeus and R. la...