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The role of protein kinase C in alpha-adrenergic regulation of NaCl(K) cotransport in human airway epithelial cells

, : The role of protein kinase C in alpha-adrenergic regulation of NaCl(K) cotransport in human airway epithelial cells. American Journal of Physiology 268(3 Pt 1): L414-L423

alpha-1-Adrenergic (alpha-1-AR) agents stimulate NaCl(K) cotransport and phosphatidylinositol-4,5-bisphosphate (PtdIns(4,5)P-2)-specific phospholipase C in human trachea and nasal polyp epithelial cells. One second messenger generated by PtdIns(4,5)P-2 degradation is inositol trisphosphate. We now show that diglycerides (DG) are also generated during alpha-1-AR stimulation.


PMID: 7900823

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