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The toxicity of fthalide in rats


, : The toxicity of fthalide in rats. Yakhak Hoeji 39(4): 450-460

The acute toxicity of fthalide in rat was studied in vivo by the observations of the changes in hematogram, serological parameters, content of cytochrome p-450, activities of NADPH-cytochrome c reductase, glucose-phosphatase, and the contents of cholinesterase and carboxylesterase in liver. Fthalide is a practically non-toxic substance(LD-50 is 3.86 g/Kg), but rats were intoxicated with fthalide at a oral dose of 100 mg/kg for 12 days WBC were significantly decreased and activities of ALT and LDH, on the contrary the content of glucose in serum were slightly increased Cytochrome p-450 and lipid peroxide in liver were significantly increased in the phthalide-intoxicated rats. The longer administration of phthalide showed further increase of carboxylesterase activity in liver and serum, but decrease of activities of glucose-6-phosphatase and cholinesterase in liver and serum. These results show that phthalide can induce the hepatocellular injury and neurotoxicity.

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