geoscience.net logo
+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

The value of antibiotics and the outcomes of antibiotic therapy in exacerbations of COPD


, : The value of antibiotics and the outcomes of antibiotic therapy in exacerbations of COPD. Chest 113(4 Suppl): 249s-255s

COPD is the fifth leading cause of death in the United States, and acute respiratory infections account for a significant proportion of all primary care visits. Approximately one half of all exacerbations of COPD can be attributed to bacterial infection, and antibiotic therapy has been demonstrated to improve clinical outcomes and hasten clinical and physiologic recovery. The major pathogen continues to be Haemophilus influenzae, and resistance to beta-lactam antibiotics such as ampicillin can be expected in 20 to 40% of isolated strains. Certain high-risk patients, in whom the cost of clinical treatment failure is high, can be identified by simple clinical criteria. Patients with significant cardiopulmonary comorbidity, frequent purulent exacerbations of COPD, advanced age, generalized debility, malnutrition, chronic corticosteroid administration, long duration of COPD, and severe underlying lung function tend to fail therapy with older drugs, such as ampicillin, and early relapse can be expected. Treatment directed toward resistant pathogens with potent bactericidal drugs may be expected to lead to improved clinical outcomes and overall lower costs, particularly if hospital admissions and respiratory failure can be prevented. Future studies examining the role of antibiotics should enroll these high-risk patients to determine if new therapies have significant clinical, quality-of-life, and economic advantages over older agents.

US$19.90

PMID: 9552014

DOI: 10.1378/chest.113.4_Supplement.249S


Other references

Koval', E.Z.; Shved, A.D., 1975: Surface structure and composition of cell walls in various fusaria species. Mikrobiolohichnyi Zhurnal 37(4): 447-454

Ponchel, A.; Hug, G.; Jaouen, M., 2001: Study of the local atomic strain field in a Zr-doped TiAl intermetallic alloy by EXAFS and ab initio FLAPW calculations. The mechanical properties of gamma-TiAl-based intermetallic alloys are strongly influenced by Ti d-Ti d and Al p-Ti d hybridizations. These directional bonds supply good mechanical properties at high temperature but they are also associated with a...

Scherz, M.W.; Matthews, R.S., 1997: Dihydrobenzothiophene compounds useful as anti-inflammatory agents. Official Gazette of the United States Patent & Trademark Office Patents 1203(1): 483, Oct 7

Minchin, E.A.; Woodcock, H.M., 1911: Observations on the Trypanosome of the Little Owl (Athene noctua) with remarks on other Protozoan parasites occurring in this bird. Quarterly Journal of Microscopical Science, 57 141-185

Mechoulam, R.; Hanu, L., 2002: The cannabinoids: an overview. Therapeutic implications in vomiting and nausea after cancer chemotherapy, in appetite promotion, in multiple sclerosis and in neuroprotection. The present paper describes the historical use of cannabis, starting with its use in Assyria and China. Recent advances in the understanding of the molecular basis of cannabis action are explained, including the identification of the cannabinoid r...

Patterson, J.F., 1983: Amoxapine-induced chorea. Southern Medical Journal 76(8): 1077-1077

Fukuhara, T., 1977: Reflection on the research on gastrointestinal motility. Nihon Heikatsukin Gakkai Zasshi 13(4): 254-256

Lok Nath; Singh, A.K.; Singh, H.M., 2004: Relative resistance of coriander (Coriandrum sativum L.) germplasm against aphid Hyadaphis coriandri. Among the coriander germplasms (ND Cor 2, ND Cor 7, ND Cor 9, ND Cor 18, ND Cor 21, ND Cor 29, ND Cor 30, ND Cor 32, ND Cor 33, ND Cor 34, ND Cor 35, ND Cor 36, ND Cor 37, ND Cor 38 and K. selection) screened under field conditions for resistance...

Fujii, N.; Ohnishi, K.; Miyai, T., 1978: The significance of hair manganese level for the exposure to manganese. 1. Factors affecting the level in nonexposed people. 1. Concentration of manganese in hair of Japanese not exposed to Mn was estimated in Tokushima, Anan and Sakaide in different years between 1968 and 1972. Concentration was log-normal in distribution, higher for women than for men. It tended to de...

Muratalla Lua, S.; Rodriguez Mendoza, M. de las N.; Sanchez Garcia, P.; Tijerina Chavez, L.; Santizo Rincon, J.A.; Lopez Jimenez, A., 2006: Corn straw as substrate in growth of tomato seedlings. Maize straw of 0.5-1 and 1-2 mm diameter, alone or combined with tezontle, was evaluated as substrate to grow tomato (Lycopersicon esculentum) seedlings. In order to eliminate phenolic acids reported as toxic for plants. Two extraction methods wer...