+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Tracheobronchial deposition and clearance in small airways in asthmatic subjects

, : Tracheobronchial deposition and clearance in small airways in asthmatic subjects. European Respiratory Journal 9(6): 1123-1129

Asthma tends to impair mucociliary clearance, as assessed from measurements in large airways. However, very little is known about clearance in the smallest airways of the tracheobronchial region. Deposition and clearance was estimated in 11 subjects with stable asymptomatic asthma and 10 healthy subjects after inhalation of 6 mu-m (aerodynamic diameter) monodisperse Teflon particles labelled with 111In. The particles were inhaled at an extremely slow flow, 0.05 L cntdot s-1. Theoretical calculations and experimental data in healthy subjects using this slow flow support an enhanced deposition in the tracheobronchial region, in particular in the small ciliated airways (bronchioles). Lung retention was measured at 0, 24, 48 and 72 h. Clearance was significant every 24 h both for asthmatic and healthy subjects, with similar fractions of retained particles at all time-points. The fractions of tracheobronchially-deposited particles were on average 41 and 47% for asthmatic and healthy subjects, respectively, as compared to a maximal deposition of 30% using a normal inhalation flow (0.5 L cntdot s-1). No significant correlation was found between lung retention and lung function, either in asthmatics or in healthy subjects. Our results indicate that particles clear equally well from small ciliated airways in asthmatic and healthy subjects, maybe as a consequence of an optimal asthma therapy. Furthermore, our results show that it is possible to enhance tracheobronchial deposition both in healthy and asthmatic subjects, i.e. practically independent of airway dimensions, by inhaling rather large aerosol particles extremely slowly. This may be a useful therapeutic approach.


PMID: 8804926

Other references

Meyer, J.S.; Howden, S.E.; Wallace, K.A.; Verhoeven, A.D.; Wright, L.S.; Capowski, E.E.; Pinilla, I.; Martin, J.M.; Tian, S.; Stewart, R.; Pattnaik, B.; Thomson, J.A.; Gamm, D.M., 2011: Optic vesicle-like structures derived from human pluripotent stem cells facilitate a customized approach to retinal disease treatment. Differentiation methods for human induced pluripotent stem cells (hiPSCs) typically yield progeny from multiple tissue lineages, limiting their utility for drug testing and autologous cell transplantation. In particular, early retina and forebrain...

Pašalić, I.; Trninić, I.; Nemir, J.; Jednačak, H.; Žarković, K.; Mrak, G., 2016: Rare Infratentorial and Supratentorial Localization of Juvenile Angiofibroma: A Case Report. NlmCategory="UNASSIGNED">Angiofibromas are rare tumors of the head and neck that mostly occur in the sphenopalatine region. We present a case of angiofibroma in a young male patient with an unusual and extremely rare localization, whi...

Zhang, L.; Ding, R.; Chai, Y.; Bonfill, M.; Moyano, E.; Oksman-Caldentey, K-Marja.; Xu, T.; Pi, Y.; Wang, Z.; Zhang, H.; Kai, G.; Liao, Z.; Sun, X.; Tang, K., 2004: Engineering tropane biosynthetic pathway in Hyoscyamus niger hairy root cultures. Scopolamine is a pharmaceutically important tropane alkaloid extensively used as an anticholinergic agent. Here, we report the simultaneous introduction and overexpression of genes encoding the rate-limiting upstream enzyme putrescine N-methyltran...

Osinovskiy V.I., 1931: Diatomaceous earth of the Kola Peninsula. Historical sketch of prospecting on Kola Peninsula for diatomite. Successful results of investigations carried out by Prof. A. A. Grigor'ev's geographical section of the expedition of the Academy of Sciences, 1930, during which diatomite...

Mills, W.B.; Lew, C.S.; Loh, J.Y., 1998: Predictions of potential human health and ecological risks from power plant discharges of total residual chlorine and chloroform into rivers. Low levels of chlorine residual and the triialomethane chloroform can be released from power plant discharges and enter natural surface water bodies. Such effluents may pose potential human health and ecological risks. To evaluate these risks; a m...

Feng, H.; Nie, W.; Bonilla, R.; Widmer, G.; Sheoran, A.; Tzipori, S., 2007: Quantitative tracking of Cryptosporidium infection in cell culture with CFSE. Immunofluorescence-based assays have been developed to detect and quantitate Cryptosporidium parvum infection in cell culture. Here, we describe a method that tracks and quantifies the early phase of attachment and invasion of C. parvum sporozoit...

Zazakowny, K.; Lewandowska-Łańcucka, J.; Mastalska-Popławska, J.; Kamiński, K.; Kusior, A.; Radecka, M.; Nowakowska, M., 2016: Biopolymeric hydrogels - nanostructured TiO 2 hybrid materials as potential injectable scaffolds for bone regeneration. NlmCategory="UNASSIGNED">The present work aims at development of novel hybrid materials from genipin crosslinked collagen or collagen/chitosan hydrogels containing various types of TiO<sub>2</sub> nanoparticles characteriz...

Tanigawara Y.; Kamiya A.; Saito Y.; Hayashi Y.; Aiba T.; Okumura K.; Hori R., 1987: Moment analysis of renal transport of drugs mean renal epithelial cell residence time of p aminohippurate in isolated perfused rat kidney. Journal of Pharmaceutical Sciences 76(11): S98

Werner, A.A., 1948: The climacteric in women and men. Postgraduate Medicine 4(2): 102-110

Seely, E.W.; Kram, K.E.; Emans, S.Jean., 2015: Developmental networks in translational science. Translational Research 165(4): 531-536