geoscience.net logo
+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Trilinolein reduces infarct size and suppresses ventricular arrhythmias in rats subjected to coronary ligation


, : Trilinolein reduces infarct size and suppresses ventricular arrhythmias in rats subjected to coronary ligation. Pharmacology 51(2): 118-126

Trilinolein, a triacylglycerol with linoleic acid as the only fatty acid residue in all esterified positions of glycerol, was previously found to improve erythrocyte deformability in vitro. In this study, the in vivo antiarrhythmic and anti-ischemic effects of trilinolein in coronary ligated rats were investigated. Male Sprague-Dawley rats were anaesthetized with urethane. Trilinolein, at dosages ranging from 10(-11) to 10(-7) g/kg, was administered intravenously 15 min before ligation of coronary artery. Also, the effect of trilinolein on arrhythmia was studied by ligating the coronary artery for 30 min, then reperfusing myocardium for 10 min. During the 30-min ischemia, trilinolein reduced not only the number of ectopic beats but also the incidence rate and duration of ventricular tachycardia. At 10(-7) g/kg, trilinolein completely suppressed all ventricular arrhythmias. Ventricular arrhythmias during 10 min reperfusion were also reduced by trilinolein at similar dosages. Furthermore, the effect of trilinolein on infarct size was evaluated by occluding the coronary artery for 4 h before the infarct zone was stained and weighed. In rats subjected to 4 h coronary ligation, pretreatment with 10(-7) g/kg trilinolein at 15 min prior to the coronary ligation significantly reduced infarct size. Trilinolein may protect myocardium against ischemic injury and suppress arrhythmia during ischemia and reperfusion.

US$29.90

PMID: 8584572


Other references

Kiaris, H.; Eliopoulos, A.; Sivridis, E.; Ergazaki, M.; Spandidos, D., 1995: Activating mutations of ras family genes in prostatic-cancer. ras family genes (H-, K- and N-ras) encode for a 21 kD membrane protein which possesses GTPase activity and participates in a signal transduction pathway. Activating mutations of the ras family genes occur at codons 12, 13 and 61 and have been det...

Szpalski, M.; Gunzburg, R., 1998: The role of surgery in the management of low back pain. The main challenge of surgery in the treatment of low back pain lies with the poor knowledge of the aetio-pathogenesis of this symptom. Surgical treatment requires the precise diagnosis of a surgically curable lesion. In low back disorders this re...

Nieuwkoop, P.D.; Oikawa, I.; Boddingius, J., 1959: The anterior transverse neural fold in amphibians. Archives Neerlandaises de Zoologie. 1958 ; 131: 167-184

Faivre, J.; Benhamiche, A.M.; Dancourt, V., 2002: Endoscopic monitoring after polypectomy. What efficacy? What rhythm?. IN THE ABSENCE OF ENDOSCOPIC MONITORING: The risk of colorectal cancer is higher than in the general population in patients presenting an adenoma with a diameter of more than 1 cm, and/or comprising villous structures and/or severe dysplasia. The...

Uysal, I., 2004: Living resources: the biodiversity of Turkey. The biodiversity of Turkey is briefly described with reference to its genetic diversity, species diversity and ecological diversity. The importance of biodiversity, its monitoring and conservation, and its potential role in tourism are discussed....

Wang, J.; Irnaten, M.; Mendelowitz, D., 2001: Agatoxin-IVA-sensitive calcium channels mediate the presynaptic and postsynaptic nicotinic activation of cardiac vagal neurons. Whole cell currents and miniature glutamatergic synaptic events (minis) were recorded in vitro from cardiac vagal neurons in the nucleus ambiguus using the patch-clamp technique. We examined whether voltage-dependent calcium channels were involved...

Werner, H.; Woloschak, M.; Adamo, M.; Shen-Orr, Z.; Roberts, C.T.; LeRoith, D., 1989: Developmental regulation of the rat insulin-like growth factor I receptor gene. We have investigated the developmental regulation of the rat insulin-like growth factor I (IGF-I) receptor gene in various tissues using a sensitive and specific solution hybridization/RNase protection assay. For this purpose we characterized rat...

Ahmed, H.; Siam, A.Ezzat.; Gouda-Mohamed, G-Mohamed.; Boehm, H., 2014: Surgical treatment of sacroiliac joint infection. Operated at our institution between January 1994 and December 201Twenty-two patients were included: 14 females and 8 males, with mean age of 50 years. The mean follow-up period was 34 months. Twenty-four operations were performed. Coinciding infec...

Gulati, G.; Cornish, R.; Al-Taiar, H.; Miller, C.; Khosla, V.; Hinds, C.; Price, J.; Geddes, J.; Fazel, S., 2016: Web-Based Violence Risk Monitoring Tool in Psychoses: Pilot Study in Community Forensic Patients. NlmCategory="UNASSIGNED">We describe the development and pilot testing of a novel, web-based, violence risk monitoring instrument for use in community patients with psychoses. We describe the development of the tool, including drawing...

Ribi, W.A., 1984: The 1st optic ganglion of the bee apis mellifera 5. structural and functional characterization of centrifugally arranged interneurons. The organization, characterization and connectivity patterns of 4 different interneuron types were studied with the use of Golgi light microscopic and EM techniques. All 4 cell types originate in the outer chiasma; they have an efferent end-branch...