geoscience.net logo
+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Trypsin enhances sympathetic neuron-dependent plasma extravasation in the rat knee joint


, : Trypsin enhances sympathetic neuron-dependent plasma extravasation in the rat knee joint. Neuroscience Letters 158(1): 117-119

Perfusion of 6-hydroxydopamine through the rat knee joint causes an increase in plasma extravasation by activation of sympathetic neuron terminals. Similarly, the increase in plasma extravasation in the rat knee joint produced by the inflammatory mediator bradykinin is dependent on the sympathetic post-ganglion neuron. There is evidence that both 6-hydroxydopamine and bradykinin release a number of mediators, some of which appear to enhance plasma extravasation and some which inhibit it. We attempted to determine the nature of inhibitory factor(s) by co-infusing trypsin (which rapidly cleaves peptides) with 6-hydroxydopamine. We observed a marked enhancement of 6-hydroxydopamine-induced plasma extravasation by trypsin. This effect appeared to be specific to neurogenic plasma extravasation since trypsin alone had little effect on plasma extravasation and trypsin did not affect non-neurogenic plasma extravasation (that produced by platelet activating factor). Taken together, the data suggests that 6-hydroxydopamine not only releases mediators from the sympathetic neuron that produce plasma extravasation, but also an inhibitor(s) of plasma extravasation that is peptide in nature.

US$19.90

PMID: 8233065

DOI: 10.1016/0304-3940(93)90626-V


Other references

Sweeney, H.L., 1994: The importance of the creatine kinase reaction: the concept of metabolic capacitance. The creatine kinase reaction is traditionally viewed as providing an energy reserve in muscle. However, the physiological importance of this reaction (and the analogous invertebrate reaction catalyzed by arginine kinase) is better understood when...

Lee, R.K.; Eaton, R.C., 1991: Identifiable reticulospinal neurons of the adult zebrafish, Brachydanio rerio. Reticulospinal neurons of the larval zebrafish Brachydanio rerio have been categorized into 27 different types (Kimmel et al.: Journal of Comparative Neurology 205:112-127, 1982; Metcalfe et al.: Journal of Comparative Neurology 251:147-159, 1986)...

Dixon, Keith L., 1963: Some aspects of social organization in the Carolina chickadee. Study of 40 color-marked Parus carolinensis (an arboreal passerine bird) for 5 years in eastern Texas revealed that dispersion as breeding pairs and aggregation in "winter" flocks of 3 to 7 individuals alternate within each annual cycle....

Kuchmin, A.N.; Rezvan, V.V.; Shevelev, A.A.; Sadykov, R.F.; Kharitonov, M.A.; Kraĭniukov, P.E.; Popov, A.V.; Sergovtsev, A.A., 2010: Peculiarities of the immune status of soldiers taken ill with extramural pneumonia during battle action. The article deals with violations of general resistance of the organism of military men, who get extramural pneumonia during the battle action. The author analyzed the data of immune status in three groups of soldiers. Statistical analysis of mate...

Kang, Y.; Kim, Y.Woon.; Yun, J.; Shin, J.; Kim, A., 2015: KLF1 stabilizes GATA-1 and TAL1 occupancy in the human β-globin locus. KLF1 is an erythroid specific transcription factor that binds to regulatory regions of erythroid genes. Binding sites of KLF1 are often found near binding sites of GATA-1 and TAL1. In the β-globin locus, KLF1 is required for forming active chroma...

Moll, R.A.; Bratkovich, A.; Chang, W.Y.B.; Pu, P., 1993: Physical, chemical, and biological conditions associated with the early stages of the Lake Michigan vernal thermal front. Estuaries 16(1): 92-103

Yoshida, D.; Fukunari, H.; Hojo, I.; Kitago, K.; Ito, M.; Nihei, Z.; Inoue, T.; Mishima, Y., 1992: Enterocolitis due to methicillin-resistant Staphylococcus aureus--report of two cases. Two cases of postoperative enterocolitis due to methicillin-resistant Staphylococcus aureus (MRSA) after gastrectomy were experienced. Case 1: A 59-year-old male underwent subtotal gastrectomy for advanced gastric cancer. Diffuse peritonitis progr...

Faseehuddin, Q.; Ali, S., 2008: Bladder flap posterior urethroplasty (Faseeh's technique). Posterior urethral distraction defects are common nowadays because of increased incidence of road traffic accidents (RTA) and FALL. Approximately 90% are associated with pelvic fracture. Initial suprapubic cystostomy followed by delayed single sta...

Dwijendra Singh; Singh, D.K., 2004: Varietal resistance of Mentha arvensis Linn. to sweet potato whitefly, Bemisia tabaci Genn. Six cultivars of Mentha arvensis (Gomti, Himalaya, Kalka, Kosi, MAS-1 and Shivalik) were evaluated for their resistance to sweetpotato whitefly (Bemisia tabaci) at Lucknow, Uttar Pradesh, India, in January 1999. The adults of B. tabaci in each cul...

Lindner, Keith W., 2013: The Struggle for La Sierra Sovereignty, property, and rights in the San Luis Valley. In 2002 the Colorado Supreme Court reversed decades of precedent in <italic>Lobato v. Taylor</italic> by awarding Hispano heirs to the Mexican-era Sangre de Cristo Land Grant renewed access rights to that grant's former communal l...