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Tumor antigen presentation: Changing the rules


, : Tumor antigen presentation: Changing the rules. Cancer Immunology Immunotherapy 46(2): 70-74

Cell-based tumor vaccines have been developed on the basis of the hypothesis that tumor cells can be genetically modified to present antigen to T lymphocytes directly. Contrary to expectations, cross-priming is the predominant pathway for activation of tumor-specific CD8+ T cells, while direct presentation of antigen dominates activation of tumor-specific CD4+ T cells. These results pose interesting paradoxes for the generation of immune responses, and have definite implications for the development of anti-cancer vaccines.

US$19.90

PMID: 9558001

DOI: 10.1007/s002620050463


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