+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Tumor antigen presentation: Changing the rules

, : Tumor antigen presentation: Changing the rules. Cancer Immunology Immunotherapy 46(2): 70-74

Cell-based tumor vaccines have been developed on the basis of the hypothesis that tumor cells can be genetically modified to present antigen to T lymphocytes directly. Contrary to expectations, cross-priming is the predominant pathway for activation of tumor-specific CD8+ T cells, while direct presentation of antigen dominates activation of tumor-specific CD4+ T cells. These results pose interesting paradoxes for the generation of immune responses, and have definite implications for the development of anti-cancer vaccines.


PMID: 9558001

DOI: 10.1007/s002620050463

Other references

Slyn'ko, V.I., 1976: Electrophoretic analysis of malate dehydrogenase isoenzymes in fish of the Salmonidae family. Doklady Akademii Nauk SSSR 226(2): 448-451

Picardo, N.E.; Khan, W.S., 2012: Advances in the understanding of the aetiology of Dupuytren's disease. Dupuytren's disease is a fibroproliferative disease of the palmar fascia which has been described for centuries, yet the aetiology and pathophysiology remain poorly understood. Surgery and collagenase injections comprise the main therapeutic...

Knypl, J.S.; Janas, K.M., 1975: Synthesis of RNA and protein, with ribonuclease activity, in carrot roots infested with Meloidogyne hapla Chitw. Roots of 5-month-old healthy and Meloidogyne hapla-infested carrot cv. Slendero (tolerant to this nematode) and cv. Perfekcja (sensitive to this nematode) were analysed. In galls which proliferated from rhizogenic plaques of the storage roots of b...

Gosler, A.G.; Harper, D.G.C., 2000: Assessing the heritability of body condition in birds A challenge exemplified by the great tit Parus major L. The definition and measurement of body condition are central to many ecological and evolutionary studies, yet the fundamental issue of whether variation in condition is inherited genetically remains unresolved. Furthermore, confusion has been caus...

Verlaat, J.G., 1977: A 20-year weed control investigation in outdoor vegetables, carried out by the Research Station for Vegetable Growing. The results are presented of herbicide trials on the following crops: endive, ridge cucumber, cauliflower, cabbage, Brussels sprouts, pea, celery, celeriac, swede, kohlrabi, beetroot, parsnip, carrot, parsley, leek, rhubarb, scorzonera, lettuce, s...

Fagan, B.M.; Cahusac, P.M., 2001: Evidence for glutamate receptor mediated transmission at mechanoreceptors in the skin. The functional role of Merkel cells in the mechanosensitivity of the slowly adapting type I responses has been a controversial issue for many years. Here we show, for the first time, that glutamate receptor-mediated transmission is largely respons...

Anonymous, 1996: Regional Plan for Investments in Environment and Health for Latin America and the Caribbean. Boletin de la Oficina Sanitaria Panamericana. Pan American Sanitary Bureau 120(6): 538-541

Dhir, V.; Shukla, S.; Haroon, N.; Chowhan, A.Kumar.; Aggarwal, A., 2007: Medical image. Arthritis and macroglossia. Multiple myeloma complicated by amyloidosis causing arthropathy. New Zealand Medical Journal 120(1254): U2534-U2534

LOGINOVA.N.D.; GODIN.L.Sh., 1964: Sound-Proof Electrically Shielded Chamber For Audiometric Examinations. Vestnik Otorinolaringologii 26: 58-62

Takeda, J.; Namiki, A.; Ozaki, M.; Fukuda, K.; Morita, K.; Kanmura, Y.; Yamakage, M.; Komatsu, T.; Inada, E.; Kawate, R.; Kanazawa, M.; Sakamoto, A.; Uezono, S.; Sato, S.; Nishiwaki, K.; Miyamoto, Y.; Nakatsuka, H.; Yasuda, N., 2014: A prospective randomized multicenter comparative study of BLM-240 (desflurane) versus sevoflurane in Japanese patients. The present study was conducted to evaluate the efficacy and safety of BLM-240 (desflurane) in comparison to sevoflurane in Japanese patients. A total of 216 patients were enrolled in this randomized comparative study at 15 medical institutions. T...