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Two Concentrations of Topical Tretinoin (Retinoic Acid) Cause Similar Improvement of Photoaging but Different Degrees of Irritation: A double-blind, vehicle-controlled comparison of 0.1 percent and 0.5 percent tretinoin creams


, : Two Concentrations of Topical Tretinoin (Retinoic Acid) Cause Similar Improvement of Photoaging but Different Degrees of Irritation: A double-blind, vehicle-controlled comparison of 0.1 percent and 0.5 percent tretinoin creams. Archives of Dermatology 131(9): 1037-1044

Background and Design: The efficacy of topical tretinoin (all-trans-retinoic acid) in treating photoaging is well established. Questions that remain are (1) whether irritation causes all or part of the improvement; (2) the concentration of tretinoin that maximizes clinical response with minimal side effects; and (3) the effects of longterm treatment on components of the cutaneous immune system.

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