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Type I collagen and procollagen fragments in patients with metabolic bone diseases


, : Type I collagen and procollagen fragments in patients with metabolic bone diseases. Journal of the Formosan Medical Association 95(7): 523-529

The purpose of the present study was to evaluate the serum levels of two new markers, and to compare their clinical usefulness with two conventional markers. Healthy women and patients with aberrant bone metabolism were evaluated for serum or urine levels of different bone markers. We measured serum levels of the pyridinoline cross-linked telopeptide domain of type 1 collagen (S-ICTP) and carboxy-terminal propeptide of type 1 procollagen (S-PICP) as markers of bone resorption and formation, respectively. These levels were compared to the concentrations of serum bone gamma-carboxyglutamic acid protein (S-BGP) and total urinary pyridinium cross-links (U-PYD). The control group included 222 premenopausal and postmenopausal women, and the disease groups consisted of 61 individuals with malignancy-associated hypercalcemia, Graves' thyrotoxicosis or primary hyperparathyroidism. Both S-PICP and S-BGP reflected higher bone turnover in postmenopausal than premenopausal women. All patient groups had significantly higher S-ICTP and U-PYD than the controls. Increased S-PICP was seen in malignancy associated hypercalcemia and Graves' thyrotoxicosis, but not in primary hyperparathyroidism, while higher S-BGP was seen in Graves' thyrotoxicosis and primary hyperparathyroidism, but not in malignancy-associated hypercalcemia. Discrepancy between S-PICP and S-BGP in malignancy-associated hypercalcemia and primary hyperparathyroidism was noted. S-ICTP and U-PYD had higher sensitivity and specificity in discriminating patients from controls. We conclude that S-ICTP is superior to U-PYD as an index of bone resorption in aberrant bone metabolism. S-PICP may also be a useful bone turnover marker but discrepancies between it and S-BGP in malignancy-associated hypercalcemia and primary hyperparathyroidism need further investigation.

US$29.90

PMID: 8840753


Other references

Christian, J.L.; Moon, R.T., 1993: Interactions between Xwnt-8 and Spemann organizer signaling pathways generate dorsoventral pattern in the embryonic mesoderm of Xenopus. This study analyzes the hierarchy of signals that spatially restrict expression of Xenopus Xwnt-8 to mesodermal cells outside of the Spemann organizer field and examines the potential role that endogenous Xwnt-8 may play in dorsoventral patterning...

Corwin, E., 1975: Opening the closed door. Fda Consumer 9(3): 24-27

Anonymous, 2016: Retraction Note to: Relationships of COX2 and MMP12 genetic polymorphisms with chronic obstructive pulmonary disease risk: a meta-analysis. Molecular Biology Reports 42(10): 1491-1491

Spinetta, J.J.; Deasy-Spinetta, P., 1986: The patient's socialization in the community and school during therapy. As medical advances have made it possible for a greater number of children with cancer to live into adulthood, the focus of concern has shifted from preparation for death to a full and active preparation for adult living. As children live longer,...

Kohen E.; Kohen C.; Hirschberg J.G.; Wouters A.W., 1980: Micro spectro fluorometry of intra cellular carcinogen interactions. Toxicology Letters (Shannon) (SPEC ISSUE 1): 20

Anonymous, 1967: Esophageal hiatal hernia. Panel discussion. American Journal of Surgery 113(1): 91-101

Nahorski, S.R.; Jenkinson, S.; Challiss, R.A., 1992: Disruption of phosphoinositide signalling by lithium. Biochemical Society Transactions 20(2): 430-434

Murthy, S.; Salas, D.; Hirekataur, S.; Ram, R., 2002: Terson's syndrome presenting as an ophthalmic emergency. Purpose: To report an unusual case of Terson's syndrome caused by a ruptured intracranial aneurysm presenting as an ophthalmic emergency with visual loss, without any neurological features at the time of presentation. Methods: Case report. A...

Finnerty, T.P., 1989: Modifying retirement benefits: problems under ERISA. Discretionary communications to employees regarding retirement benefits must be closely monitored--or else the employer may find its right to modify benefits has been damaged.

Bhuyan K.C.; Bhuyan D.K.; Podos S.M., 1981: Evidence of increased lipid per oxidation in cataracts. IRCS (International Research Communications System) Medical Science Library Compendium 9(2): 126-127