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Urinary N-acetyl-beta-glucosaminidase activity in type I diabetes mellitus

, : Urinary N-acetyl-beta-glucosaminidase activity in type I diabetes mellitus. Annals of Clinical Biochemistry 32: 58-62

A commercial method for N-acetyl-beta-glucosaminidase (NAG) is described for use on a discrete analyser. Timed overnight urine was obtained from 20 healthy volunteers and 60 Type I diabetic patients for estimation of NAG (expressed in relation to creatinine) and albumin excretion rate (AER). The upper reference limit for NAG excretion in the control patients was found to be 0.25 U/mmol creatinine but was abnormally raised in 60% of Type I diabetic patients before any increase in AER (greater than 20 micrograms/min), and in 82% of patients with AER greater than 200 micrograms/min. A positive correlation was found between NAG excretion and AER in Type I diabetes (r = 0.61, p < 0.01), but not with glycaemic control as measured by serum fructosamine levels. We conclude that measurement of NAG excretion in diabetes indicates renal tubular dysfunction or damage before any significant change in albumin excretion rate.


PMID: 7762951

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Cheng, L.; Pricolo, V.; Biancani, P.; Behar, J., 2008: Overexpression of progesterone receptor B increases sensitivity of human colon muscle cells to progesterone. Colon muscle strips and cells from female patients with slow-transit constipation (STC) exhibit impaired motility, signal transduction abnormalities characterized by downregulation of Gq/11 and upregulation of Gs proteins, decreased cyclooxygenase...

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Okuma, M., 1972: Ultrastructural observations of the choroid and the pigment epithelium on experimental retinal detachment. 3. Scanning electron microscopic observations of the retinal pigment epithelium. Nippon Ganka Gakkai Zasshi 76(7): 377-384

Hanson J.; Ruredzo T.J., 1992: In vitro culture techniques for forage genetic resources. Moss, J P (Ed ) Biotechnology And Crop Improvement in Asia; Meeting, Patancheru, Andhra Pradesh, India, December 3-7, 1990 Ix+385p Icrisat (International Crops Research Institute For The Semi-Arid Tropics): Patancheru, Andhra Pradesh, India Illus Maps Paper 149-151

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