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Use of a novel system for defining a gene imprinting region

, : Use of a novel system for defining a gene imprinting region. Biochemical & Biophysical Research Communications 196(2): 659-664

Gene imprinting involves the expression of a single allele, depending on its parental origin. In this report, we describe the use of a novel system, implementing human tissues exclusively endowed with either maternally or paternally inherited chromosomes, to better define a known gene imprinting region. Specific RNA transcripts for Placental Ribonuclease Inhibitor (PRI) and Cathepsin D were analysed by northern blotting for expression in complete hydatidiform mole, mature teratoma, and normal placenta. These genes are in close proximity to the reciprocally imprinted H19 and IGF-2 genes found on chromosome 11p15.5. Since all the tissues studied expressed Cathepsin D and PRI, these are not, by definition, imprinted, but as yet we cannot define the borders of the imprinting area on chromosome 11p15.5.


PMID: 7694575

DOI: 10.1006/bbrc.1993.2300

Other references

Kumagai, K.; Miki, M.; Kawano, E.; Mitsuda, S., 1995: Process for production of biotin using bacteria belonging to the genus sphingomonas. Official Gazette of the United States Patent & Trademark Office Patents 1176(2): 1125, July 11

Barriga B.P.; Carillo L.B.; Fuentes P.R.; Fuentealba A.J., 1981: Photosynthetic efficiency and its relationship to yield in triticale and wheat. Ten hexaploid spring triticales were compared with five spring wheats at a single site in 1978. On average, the photosynthetic efficiency of the flag leaf blade was greater in the triticales than in the wheats. Significant intervarietal difference...

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Erdman, TC., 1979: Boreal owl in NE Wisconsin. Passenger Pigeon, 412: 58-59

Sikri K.L.; Foster C.L.; Marshall R.D., 1985: Localization of tamm horsfall glycoprotein like immunoreactivity in cultured baby hamster kidney cells shown by immunofluorescence and by light microscopic and electron microscopic immunoperoxidase techniques. Tamm-Horsfall glycoprotein was isolated from hamster urine, and an antiserum against it was produced in rabbits. IgG was isolated from the antiserum. Immunocytochemical methods were used to localize Tamm-Horsfall-like immunoreactivity in 3 substra...

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Ambanelli, U.; Maini, M.; Ferraccioli, F.; Serventi, G., 1975: Serum variations in alpha 1 t glyco protein during rheumatoid inflammation. Serum levels of .alpha.-1-T-glycoprotein (GP) in 21 cases of rheumatoid arthritis were compared with various indexes of inflammation, proteins with an important role in rheumatoid inflammation, antiproteases responsible for natural defense against...

Schott, L., 1975: The subsistence behavior of lower paleolithic man from the aspect of paleo neurological knowledge and hypotheses. In subsistence hunting the ability to retain a proposition for longer or shorter time in memory and to anticipate results is of decisive importance. Spatial imaginative faculty generally is necessary for successful hunting activity. Relations of t...

Blattner, W.A.; Dean, J.H.; Fraumeni, J.F., 1979: Familial lymphoproliferative malignancy: clinical and laboratory follow-up. Annals of Internal Medicine 90(6): 943-944