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Variability of mitomycin C adsorption by activated charcoal

, : Variability of mitomycin C adsorption by activated charcoal. Journal of Pharmacy & Pharmacology 50(3): 251-256, March

A saline suspension of mitomycin C adsorbed on activated charcoal and administered intraperitoneally has been reported to be safe and effective in the treatment of gastric carcinoma. Activated charcoal specifically targets tumour and lymph-node tissues and the sustained higher local drug concentration is thought to be beneficial. The charcoal particles used in these suspensions have varied in size from > 147 microm to < 20 nm in diameter, but no data have been published to show how this might affect drug adsorption and delivery. Any variability in drug adsorption could pose a serious clinical risk for drugs with a narrow therapeutic index. We have, therefore, investigated the adsorption of mitomycin C on activated charcoal in-vitro. Activated charcoal was ground and sieved to yield four size-fractions between 180 and 53 microm. Adsorption isotherms (n > or = 3) were constructed and applied to the Freundlich model with 0-l00 microg mL(-1) mitomycin C measured by HPLC with detection at 365 nm. Adsorption of mitomycin C by activated charcoal varied by a factor of three under identical conditions at room temperature (21 degrees C) and at 37 degrees C. The specific adsorption (microg mitomycin C (mg activated charcoal)(-1)) was generally higher at 37 degrees C than at room temperature. The variability of mitomycin C adsorption was greatly reduced by addition of the surface-active agent polyvinylpyrollidone, used to determine that adsorption of mitomycin C was independent of activated charcoal particle size. The characteristics of adsorption of mitomycin C by activated charcoal are complex and should be thoroughly investigated to discover the critical controlling factors before submitting the suspensions for further clinical evaluation.


PMID: 9600715

DOI: 10.1111/j.2042-7158.1998.tb06857.x

Other references

Wright, Gm, 1977: Review of the seasons, 1977-79. New Zealand wheat review: 79 (14) 49-52

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Mcanulty, J.M.; Keene, W.E.; Fleming, D.W., 1993: A water system in one town causing an outbreak of cryptosporidiosis in another town. Program & Abstracts of the Interscience Conference on Antimicrobial Agents & Chemotherapy 33(0): 387

Ritch, D.L.; Drew, D.W., 1967: Coronary embolism with myocardial infarction and septic meningitis in a young female with subacute bacterial endocarditis. Virginia Medical Monthly 94(4): 224-228

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Schull, L., 1949: Respiratory and cardiac emergencies during anesthesia. Journal of the American Association of Nurse Anesthetists 17(2): 125-130

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